Literature DB >> 18158922

Induction of podoplanin by transforming growth factor-beta in human fibrosarcoma.

Hiroyuki Suzuki1, Yukinari Kato, Mika Kato Kaneko, Yukari Okita, Hisashi Narimatsu, Mitsuyasu Kato.   

Abstract

Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-beta (TGF-beta) regulates many physiological events, including tumorigenesis. Here, we found that TGF-beta induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-beta type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-beta. These results suggest that TGF-beta is a physiological regulator of podoplanin in tumor cells.

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Year:  2007        PMID： 18158922     DOI： 10.1016/j.febslet.2007.12.028

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  19 in total

1.  Increased lymphatic vessels in patients with encapsulating peritoneal sclerosis.

Authors:  Tatsuhiro Yaginuma; Izumi Yamamoto; Hiroyasu Yamamoto; Jun Mitome; Yudo Tanno; Keitaro Yokoyama; Takenori Hayashi; Tetsuya Kobayashi; Michiaki Watanabe; Yutaka Yamaguchi; Tatsuo Hosoya
Journal:  Perit Dial Int       Date:  2012-06-01       Impact factor: 1.756

2.  Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas.

Authors:  Yukinari Kato; Ganesan Vaidyanathan; Mika Kato Kaneko; Kazuhiko Mishima; Nidhi Srivastava; Vidyalakshmi Chandramohan; Charles Pegram; Stephen T Keir; Chien-Tsun Kuan; Darell D Bigner; Michael R Zalutsky
Journal:  Nucl Med Biol       Date:  2010-10       Impact factor: 2.408

3.  TGFβ and Hippo Pathways Cooperate to Enhance Sarcomagenesis and Metastasis through the Hyaluronan-Mediated Motility Receptor (HMMR).

Authors:  Shuai Ye; Ying Liu; Ashley M Fuller; Rohan Katti; Gabrielle E Ciotti; Susan Chor; Md Zahidul Alam; Samir Devalaraja; Kristin Lorent; Kristy Weber; Malay Haldar; Michael A Pack; T S Karin Eisinger-Mathason
Journal:  Mol Cancer Res       Date:  2020-01-27       Impact factor: 5.852

4.  Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma.

Authors:  Akiko Kunita; Takeshi G Kashima; Atsushi Ohazama; Agamemnon E Grigoriadis; Masashi Fukayama
Journal:  Am J Pathol       Date:  2011-06-12       Impact factor: 4.307

5.  Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2.

Authors:  Chawaree Chaipan; Imke Steffen; Theodros Solomon Tsegaye; Stephanie Bertram; Ilona Glowacka; Yukinari Kato; Jan Schmökel; Jan Münch; Graham Simmons; Rita Gerardy-Schahn; Stefan Pöhlmann
Journal:  Retrovirology       Date:  2010-05-19       Impact factor: 4.602

6.  Ezrin-expressing lung adenocarcinoma cells and podoplanin-positive fibroblasts form a malignant microenvironment.

Authors:  Shigeki Suzuki; Genichiro Ishii; Rie Matsuwaki; Shinya Neri; Hiroko Hashimoto; Chisako Yamauchi; Keiju Aokage; Tomoyuki Hishida; Junji Yoshida; Mitsutomo Kohno; Kanji Nagai; Atsushi Ochiai
Journal:  J Cancer Res Clin Oncol       Date:  2014-10-11       Impact factor: 4.553

7.  The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis.

Authors:  Anna-Karin H Ekwall; Thomas Eisler; Christian Anderberg; Chunsheng Jin; Niclas Karlsson; Mikael Brisslert; Maria I Bokarewa
Journal:  Arthritis Res Ther       Date:  2011-03-07       Impact factor: 5.156

Review 8.  The Role of CLEC-2 and Its Ligands in Thromboinflammation.

Authors:  Danyang Meng; Man Luo; Beibei Liu
Journal:  Front Immunol       Date:  2021-06-09       Impact factor: 7.561

9.  Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.

Authors:  Yukari Okita; Atsushi Kamoshida; Hiroyuki Suzuki; Ken Itoh; Hozumi Motohashi; Kazuhiko Igarashi; Masayuki Yamamoto; Tomohiro Ogami; Daizo Koinuma; Mitsuyasu Kato
Journal:  J Biol Chem       Date:  2013-06-04       Impact factor: 5.157

10.  Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability.

Authors:  E Martín-Villar; B Borda-d'Agua; P Carrasco-Ramirez; J Renart; M Parsons; M Quintanilla; G E Jones
Journal:  Oncogene       Date:  2014-12-08       Impact factor: 9.867
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