Literature DB >> 18158569

Expression of connective tissue growth factor (CTGF/CCN2) in a mouse model of rhabdomyosarcomagenesis.

Stefania Croci1, Lorena Landuzzi, Giordano Nicoletti, Arianna Palladini, Agnese Antognoli, Carla De Giovanni, Patrizia Nanni, Pier-Luigi Lollini.   

Abstract

Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich matricellular protein that belongs to the CCN (CYR61, CTGF, NOV) protein family. It is highly expressed by human rhabdomyosarcoma cells and sustains their survival. In this study we investigated CCN2 expression in a mouse model of spontaneous rhabdomyosarcomagenesis that combines HER-2/neu oncogene activation and p53 oncosuppressor gene inactivation (BALB-p53neu mice). Murine rhabdomyosarcoma cells showed a 4-26 fold increase in CCN2 mRNA expression regarding to normal thigh muscle. Moreover, they expressed CCN2 protein at levels comparable to human rhabdomyosarcoma cells. Therefore BALBp53neu mice might be useful for the evaluation of the role played by CCN2 in rhabdomyosarcoma in vivo.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18158569     DOI： 10.1007/bf02940313

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  12 in total

1.  Endothelin-3 production by human rhabdomyosarcoma: a possible new marker with a paracrine role.

Authors:  Arianna Palladini; Annalisa Astolfi; Stefania Croci; Carla De Giovanni; Giordano Nicoletti; Angelo Rosolen; Francesca Sartori; Pier-Luigi Lollini; Lorena Landuzzi; Patrizia Nanni
Journal:  Eur J Cancer       Date:  2006-01-24       Impact factor: 9.162

2.  Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer.

Authors:  Tsuyoshi Shimo; Satoshi Kubota; Norie Yoshioka; Soichiro Ibaragi; Sachiko Isowa; Takanori Eguchi; Akira Sasaki; Masaharu Takigawa
Journal:  J Bone Miner Res       Date:  2006-07       Impact factor: 6.741

3.  Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis.

Authors:  Feng Yang; Jennifer A Tuxhorn; Steven J Ressler; Stephanie J McAlhany; Truong D Dang; David R Rowley
Journal:  Cancer Res       Date:  2005-10-01       Impact factor: 12.701

4.  Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer.

Authors:  Takuma Aikawa; Jason Gunn; Suzanne M Spong; Stephen J Klaus; Murray Korc
Journal:  Mol Cancer Ther       Date:  2006-05       Impact factor: 6.261

5.  Connective tissue growth factor inhibits metastasis and acts as an independent prognostic marker in colorectal cancer.

Authors:  Been-Ren Lin; Cheng-Chi Chang; Ting-Fang Che; Szu-Ta Chen; Robert Jeen-Chen Chen; Ching-Yao Yang; Yung-Ming Jeng; Jin-Tung Liang; Po-Huang Lee; King-Jen Chang; Yat-Pang Chau; Min-Liang Kuo
Journal:  Gastroenterology       Date:  2005-01       Impact factor: 22.682

6.  Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis.

Authors:  Nadja Dornhöfer; Suzanne Spong; Kevin Bennewith; Ali Salim; Stephen Klaus; Neeraja Kambham; Carol Wong; Fiona Kaper; Patrick Sutphin; Randall Nacamuli; Rendall Nacalumi; Michael Höckel; Quynh Le; Michael Longaker; George Yang; Albert Koong; Amato Giaccia
Journal:  Cancer Res       Date:  2006-06-01       Impact factor: 12.701

Review 7.  CCN proteins: multifunctional signalling regulators.

Authors:  Bernard Perbal
Journal:  Lancet       Date:  2004-01-03       Impact factor: 79.321

8.  Inhibition of connective tissue growth factor (CTGF/CCN2) expression decreases the survival and myogenic differentiation of human rhabdomyosarcoma cells.

Authors:  Stefania Croci; Lorena Landuzzi; Annalisa Astolfi; Giordano Nicoletti; Angelo Rosolen; Francesca Sartori; Matilde Y Follo; Noelynn Oliver; Carla De Giovanni; Patrizia Nanni; Pier-Luigi Lollini
Journal:  Cancer Res       Date:  2004-03-01       Impact factor: 12.701

9.  Identification of glycosylated 38-kDa connective tissue growth factor (IGFBP-related protein 2) and proteolytic fragments in human biological fluids, and up-regulation of IGFBP-rP2 expression by TGF-beta in Hs578T human breast cancer cells.

Authors:  D H Yang; H S Kim; E M Wilson; R G Rosenfeld; Y Oh
Journal:  J Clin Endocrinol Metab       Date:  1998-07       Impact factor: 5.958

10.  A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis.

Authors:  Nathalie Planque; Bernard Perbal
Journal:  Cancer Cell Int       Date:  2003-08-22       Impact factor: 5.722
View more
  5 in total

1.  Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells.

Authors:  Y Zhang; C Wang
Journal:  Oncogene       Date:  2011-03-21       Impact factor: 9.867

2.  Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes.

Authors:  Paul-Martin Holterhus; Jan-Hendrik Bebermeier; Ralf Werner; Janos Demeter; Annette Richter-Unruh; Gunnar Cario; Mahesh Appari; Reiner Siebert; Felix Riepe; James D Brooks; Olaf Hiort
Journal:  BMC Genomics       Date:  2009-07-01       Impact factor: 3.969

3.  Role of the CCN protein family in cancer.

Authors:  Hyungjoo Kim; Seogho Son; Incheol Shin
Journal:  BMB Rep       Date:  2018-10       Impact factor: 4.778

Review 4.  Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).

Authors:  Jun Li; Lin Ye; Sioned Owen; Hoi Ping Weeks; Zhongtao Zhang; Wen G Jiang
Journal:  Int J Mol Med       Date:  2015-10-23       Impact factor: 4.101

Review 5.  CCN proteins in the musculoskeletal system: current understanding and challenges in physiology and pathology.

Authors:  Veronica Giusti; Katia Scotlandi
Journal:  J Cell Commun Signal       Date:  2021-07-06       Impact factor: 5.782
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.