| Literature DB >> 18157117 |
Masayuki Kai1, Kazuhiro Motoki, Hideaki Yoshida, Chie Emuta, Yukiko Chisaka, Kumi Tsuruhata, Chisato Endo, Mari Muto, Munetake Shimabe, Uichi Nishiyama, Tetsuya Hagiwara, Atsushi Matsumoto, Hiroshi Miyazaki, Shiro Kataoka.
Abstract
We enhanced the activities of two agonist antibodies specific for the thrombopoietin receptor (c-MPL) by switching domains within their constant regions to those of different antibody isotypes. Our results suggest the importance of the hinge region in modulating agonist activity. The antibodies' thrombopoietin-like activity in vitro and in vivo, as well as the desirable pharmacokinetic profile conferred by retaining the whole-IgG structure, suggests that they provide a valuable option for treating thrombocytopenia.Entities:
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Year: 2007 PMID： 18157117 DOI： 10.1038/nbt1376
Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908