Literature DB >> 18156807

Paradoxes of aging.

Mikhail V Blagosklonny1.   

Abstract

Insightful articles by Kirkwood and other outstanding scientists reveal paradoxes of aging. The source of paradoxes is an assumption that aging is caused by random, cumulative molecular damage. Here I demonstrate that a concept of TOR-driven program-like aging almost automatically resolves eleven paradoxes of aging. This article discusses why the accumulation of molecular damage does not limit life span, why calorie restriction and inhibition of protein synthesis extend life span, why the non-existing 'program' for aging is nevertheless robust, why a key gene for aging cannot be found by knocking it out, why low insulin is associated with good health but low insulin response with bad health, why aging is not a disease but can be treated as a disease, why 'healthy' aging is slow aging, and how we know that calorie restriction actually slows aging in humans.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 18156807     DOI: 10.4161/cc.6.24.5124

Source DB:  PubMed          Journal:  Cell Cycle        ISSN: 1551-4005            Impact factor:   4.534


  43 in total

Review 1.  Dynamic energy budget approaches for modelling organismal ageing.

Authors:  Ingeborg M M van Leeuwen; Julio Vera; Olaf Wolkenhauer
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2010-11-12       Impact factor: 6.237

Review 2.  Detoxification reactions: relevance to aging.

Authors:  Piotr Zimniak
Journal:  Ageing Res Rev       Date:  2008-05-02       Impact factor: 10.895

3.  Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan.

Authors:  Michelle T Burstein; Pavlo Kyryakov; Adam Beach; Vincent R Richard; Olivia Koupaki; Alejandra Gomez-Perez; Anna Leonov; Sean Levy; Forough Noohi; Vladimir I Titorenko
Journal:  Cell Cycle       Date:  2012-08-16       Impact factor: 4.534

4.  Predicting clonal self-renewal and extinction of hematopoietic stem cells.

Authors:  Hans B Sieburg; Betsy D Rezner; Christa E Muller-Sieburg
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-28       Impact factor: 11.205

Review 5.  Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

Authors:  David Gems; Yila de la Guardia
Journal:  Antioxid Redox Signal       Date:  2012-09-24       Impact factor: 8.401

6.  Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".

Authors:  Hong Zhao; Jurek Dobrucki; Paulina Rybak; Frank Traganos; H Dorota Halicka; Zbigniew Darzynkiewicz
Journal:  Cytometry A       Date:  2011-09-08       Impact factor: 4.355

7.  miR-17-92 cluster: ups and downs in cancer and aging.

Authors:  Johannes Grillari; Matthias Hackl; Regina Grillari-Voglauer
Journal:  Biogerontology       Date:  2010-05-01       Impact factor: 4.277

8.  Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy.

Authors:  Donald J McCrann; Dan Yang; Hongjie Chen; Shannon Carroll; Katya Ravid
Journal:  Cell Cycle       Date:  2009-03-21       Impact factor: 4.534

9.  Hypoxia and gerosuppression: the mTOR saga continues.

Authors:  Olga V Leontieva; Mikhail V Blagosklonny
Journal:  Cell Cycle       Date:  2012-09-17       Impact factor: 4.534

10.  Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation.

Authors:  Hong Zhao; Frank Traganos; Anthony P Albino; Zbigniew Darzynkiewicz
Journal:  Cell Cycle       Date:  2008-03-18       Impact factor: 4.534

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.