BACKGROUND: The association between obesity and asthma severity remains controversial and limited to small studies. METHODS: We determined the association of body mass index (BMI) and asthma severity in the National Asthma Survey. We included adults (age > or = 18 years) who self-reported symptoms of asthma in the past 5 years. A total of 3095 patients were divided into the following BMI categories: 1080 (35%) non-overweight (BMI < 25), 993 (32%) overweight (BMI > or = 25 and < 30) and 1022 (33%) obese (BMI > or = 30). Asthma severity measures included respiratory symptoms, healthcare utilisation, medication use, missed work days and the Global Initiative for Asthma (GINA) severity classification. Models were adjusted for: gender, race, age, education, income, employment status, smoking status, family history of asthma, state of residence and residence in a metropolitan statistical area. RESULTS: Compared with non-overweight subjects, obese subjects with asthma were more likely to report continuous symptoms (OR 1.66, 95% CI 1.09 to 2.54), miss more work days (OR 1.35, 95% CI 1.01 to 1.81), use short acting beta agonists (OR 1.36, 95% CI 1.06 to 1.75), use inhaled corticosteroids (OR 1.34, 95% CI 1.01 to 1.79) and use any controller medication according to GINA guidelines (OR 1.37, 95% CI 1.01 to 1.85). Also, obese respondents were less likely to be in asthma remission (OR 0.56, 95% CI 0.38 to 0.82) and were more likely to have severe persistent asthma (GINA IV) (OR 1.42, 95% CI 1.05 to 1.90). CONCLUSIONS: In a large, diverse sample of adults with asthma, obesity was associated with measures of asthma severity after adjusting for potential confounders.
BACKGROUND: The association between obesity and asthma severity remains controversial and limited to small studies. METHODS: We determined the association of body mass index (BMI) and asthma severity in the National Asthma Survey. We included adults (age > or = 18 years) who self-reported symptoms of asthma in the past 5 years. A total of 3095 patients were divided into the following BMI categories: 1080 (35%) non-overweight (BMI < 25), 993 (32%) overweight (BMI > or = 25 and < 30) and 1022 (33%) obese (BMI > or = 30). Asthma severity measures included respiratory symptoms, healthcare utilisation, medication use, missed work days and the Global Initiative for Asthma (GINA) severity classification. Models were adjusted for: gender, race, age, education, income, employment status, smoking status, family history of asthma, state of residence and residence in a metropolitan statistical area. RESULTS: Compared with non-overweight subjects, obese subjects with asthma were more likely to report continuous symptoms (OR 1.66, 95% CI 1.09 to 2.54), miss more work days (OR 1.35, 95% CI 1.01 to 1.81), use short acting beta agonists (OR 1.36, 95% CI 1.06 to 1.75), use inhaled corticosteroids (OR 1.34, 95% CI 1.01 to 1.79) and use any controller medication according to GINA guidelines (OR 1.37, 95% CI 1.01 to 1.85). Also, obese respondents were less likely to be in asthma remission (OR 0.56, 95% CI 0.38 to 0.82) and were more likely to have severe persistent asthma (GINA IV) (OR 1.42, 95% CI 1.05 to 1.90). CONCLUSIONS: In a large, diverse sample of adults with asthma, obesity was associated with measures of asthma severity after adjusting for potential confounders.
Authors: Anne E Dixon; Emmanuelle M Clerisme-Beaty; Elizabeth A Sugar; Rubin I Cohen; Jason E Lang; Ellen D Brown; Joel E Richter; Charles G Irvin; John G Mastronarde Journal: J Asthma Date: 2011-08-08 Impact factor: 2.515
Authors: Omar A Al-Rawas; B Jayakrishnan; Fatma Ben Abid; Jojy George; Sawsan A Baddar; Bazdawi M Al-Riyami Journal: Sultan Qaboos Univ Med J Date: 2009-06-30
Authors: Kim D Lu; Krikor Manoukian; Shlomit Radom-Aizik; Dan M Cooper; Stanley P Galant Journal: Pediatr Exerc Sci Date: 2015-11-30 Impact factor: 2.333
Authors: Sheryl J Kopel; Natalie Walders-Abramson; Elizabeth L McQuaid; Ronald Seifer; Daphne Koinis-Mitchell; Robert B Klein; Marianne Z Wamboldt; Gregory K Fritz Journal: Biol Psychol Date: 2009-11-24 Impact factor: 3.251