| Literature DB >> 18156494 |
Marc Tjwa1, Lola Bellido-Martin, Yuan Lin, Esther Lutgens, Stéphane Plaisance, Françoise Bono, Nathalie Delesque-Touchard, Caroline Hervé, Rute Moura, An D Billiau, Cristina Aparicio, Marcel Levi, Mat Daemen, Mieke Dewerchin, Florea Lupu, Jef Arnout, Jean-Marc Herbert, Mark Waer, Pablo García de Frutos, Björn Dahlbäck, Peter Carmeliet, Marc F Hoylaerts, Lieve Moons.
Abstract
The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.Entities:
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Year: 2007 PMID： 18156494 DOI： 10.1182/blood-2007-05-089565
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113