| Literature DB >> 18155830 |
Ilse Novak-Hofer1, Susan Cohrs, Jürgen Grünberg, Alexandra Friedli, Monika C Schlatter, Marco Pfeifer, Peter Altevogt, P August Schubiger.
Abstract
Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells. A combination of mAb chCE7 and Genistein strongly reduced the sensitivity of p44/42 (Erk1,2) kinase, Src kinase and Akt kinase to extracellular stimulation with serum, Epidermal Growth Factor and Hepatocyte Growth Factor. The observed synergy of antibodies directed against L1 with Genistein could lead to a new therapeutic option for ovarian cancer.Entities:
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Year: 2007 PMID： 18155830 DOI： 10.1016/j.canlet.2007.11.012
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679