| Literature DB >> 18155657 |
Yukiteru Ouji1, Masahide Yoshikawa, Kei Moriya, Mariko Nishiofuku, Ryosuke Matsuda, Shigeaki Ishizaka.
Abstract
Although Wnts are expressed in hair follicles throughout life from embryo to adult, and considered to be critical for their development and maturation, their roles remain largely unknown. In the present study, we investigated the effects of Wnts (Wnt-3a, Wnt-5a, Wnt-10b, and Wnt-11) on epithelial cell differentiation using adult mouse-derived primary skin epithelial cell (MPSEC) cultures and hair growth using hair follicle organ cultures. Only Wnt-10b showed evident promotion of epithelial cell differentiation and hair shaft growth, in contrast to Wnt-3a, 5a, and 11. Our results suggest that Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle.Entities:
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Year: 2007 PMID： 18155657 DOI： 10.1016/j.bbrc.2007.12.091
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575