| Literature DB >> 18155417 |
Aymeric Binard1, Laëtitia Le Pottier, Alain Saraux, Valérie Devauchelle-Pensec, Jacques-Olivier Pers, Pierre Youinou.
Abstract
Given the prominent role currently assigned to B lymphocytes in systemic lupus erythematosus, it is not surprising that the B cell activity factor belonging to the tumor necrosis factor family (BAFF) is involved in its pathogenesis. This cytokine is produced in excess, and inserted into its receptors on the surface of circulating B cells. Up-regulation of BAFF is most likely to lead to breach of tolerance by aberrant survival of B cells directed to the self. Trials aimed at blocking BAFF have thus been set out. Yet the results are awaited.Entities:
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Year: 2007 PMID： 18155417 DOI： 10.1016/j.jaut.2007.11.001
Source DB: PubMed Journal: J Autoimmun ISSN： 0896-8411 Impact factor: 7.094