| Literature DB >> 18155322 |
Christophe D Proulx1, Brian J Holleran, Pierre Lavigne, Emanuel Escher, Gaétan Guillemette, Richard Leduc.
Abstract
The urotensin II receptor (UT) is a member of the G protein-coupled receptor (GPCR) family and binds the cyclic undecapeptide urotensin II (U-II) as well as the octapeptide urotensin II-related peptide (URP). The active UT mediates pleiotropic effects through various signal transduction pathways, including coupling to G proteins and activating the mitogen-activated protein kinase pathway. Several highly conserved residues and motifs of class A GPCRs that are important for activity are found in UT. This review highlights some of the putative roles of these motifs in the binding, activation and desensitization of UT.Entities:
Mesh：
Substances：
Year: 2007 PMID： 18155322 DOI： 10.1016/j.peptides.2007.10.027
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750