Literature DB >> 181535

Transformation of human embryonic fibroblasts by photodynamically inactivated herpes simplex virus, type 2 at supra-optimal temperature.

L S Kucera, J P Gusdon.   

Abstract

Infection of human embryonic fibroblast cell monolayers with neutral red and light-inactivated herpes simplex virus, type 2 (HSV-2) at supra-optimal temperature (42 degrees C) resulted in persistence of viable cells in suspension culture at 37 degrees C which have properties in common with virus transformed cells: formation of cell aggregates, HSV-2-specific antigens and colony formation in soft methyl cellulose medium. These data are consistent with the idea that photodynamic inactivated HSV-2 has potential oncogenic activity.

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Year:  1976        PMID： 181535     DOI： 10.1099/0022-1317-30-2-257

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  9 in total

1.  Herpes simplex virus type 2 functions expressed during stimulation of human cell DNA synthesis.

Authors:  L S Kucera; I Edwards
Journal:  J Virol       Date:  1979-01       Impact factor: 5.103

2.  Effect of actinomycin D on the expression of herpes simplex virus-common surface antigen in cells transformed by herpes simplex virus type 2.

Authors:  S Kimura; K Okazaki; N Yoshida; Y Ohnishi
Journal:  J Virol       Date:  1979-01       Impact factor: 5.103

3.  Mechanisms of expression of herpes simplex virus-common surface antigens in clonal cells of a herpes simplex virus type 2-transformed line.

Authors:  K Okazaki; Y Ohnishi; N Yoshida; S Kimura
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103

4.  Detection of herpes simplex virus type 2 glycoproteins expressed in virus-transformed rat cells.

Authors:  J G Lewis; L S Kucera; R Eberle; R J Courtney
Journal:  J Virol       Date:  1982-04       Impact factor: 5.103

5.  Biochemical transformation by temperature-sensitive mutants of herpes simplex virus type 1.

Authors:  F Rapp; N Turner; P A Schaffer
Journal:  J Virol       Date:  1980-06       Impact factor: 5.103

6.  Consequences of herpes simplex virus type 2 and human cell interaction at supraoptimal temperatures.

Authors:  M J Marcon; L S Kucera
Journal:  J Virol       Date:  1976-10       Impact factor: 5.103

7.  Phospholipid synthesis in human embryo fibroblasts infected with herpes simplex virus type 2.

Authors:  L W Daniel; M Waite; L S Kucera; L King; I Edwards
Journal:  Lipids       Date:  1981-09       Impact factor: 1.880

8.  Expression of an early, nonstructural antigen of herpes simplex virus in cell transformed in vitro by herpes simplex virus.

Authors:  V L Flannery; R J Courtney; P A Schaffer
Journal:  J Virol       Date:  1977-01       Impact factor: 5.103

9.  Transformation of rodent cells by a cloned DNA fragment of herpes simplex virus type 2.

Authors:  D A Galloway; J K McDougall
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103
  9 in total

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