Literature DB >> 1814634

Biosynthesis of beta-(isoxazolin-5-on-2-yl)alanine, the precursor of the neurotoxic amino acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid.

F Ikegami1, S Itagaki, T Ishikawa, G Ongena, Y H Kuo, F Lambein, I Murakoshi.   

Abstract

beta-(Isoxazolin-5-on-2-yl)alanine (BIA), a biosynthetic precursor of the neurotoxic amino acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), was confirmed to be derived from O-acetyl-L-serine (OAS) and isoxazolin-5-one by cysteine synthase in higher plants. Some properties of this enzyme in the biosynthesis of BIA are described.

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Year:  1991        PMID: 1814634     DOI: 10.1248/cpb.39.3376

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  2 in total

Review 1.  β-N-Oxalyl-l-α,β-diaminopropionic Acid (β-ODAP) Content in Lathyrus sativus: The Integration of Nitrogen and Sulfur Metabolism through β-Cyanoalanine Synthase.

Authors:  Quanle Xu; Fengjuan Liu; Peng Chen; Joseph M Jez; Hari B Krishnan
Journal:  Int J Mol Sci       Date:  2017-02-28       Impact factor: 5.923

2.  Biosynthesis of plant hemostatic dencichine in Escherichia coli.

Authors:  Wenna Li; Zhao Zhou; Xianglai Li; Lin Ma; Qingyuan Guan; Guojun Zheng; Hao Liang; Yajun Yan; Xiaolin Shen; Jia Wang; Xinxiao Sun; Qipeng Yuan
Journal:  Nat Commun       Date:  2022-09-19       Impact factor: 17.694

  2 in total

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