Literature DB >> 18145

Effects of starvation and development on mitochondrial acetoacetyl-coenzyme A thiolase of rat liver.

W D Reed, P T Ozand, J T Tildon, M Cornblath.   

Abstract

The activity of the putative ketogenic beta-oxoacyl-CoA thiolase from mitochondria of rat liver increases with starvation, during neonatal life, and after the injection of glucagon. These changes are associated with alteration in ketonaemia. The changes in activities of this species of thiolase are not associated with significant alterations in the apparent affinity (Km) for the ketogenic substrate, acetyl-CoA. These results support a role for thiolase in the regulation of ketogenesis.

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Year:  1977        PMID： 18145      PMCID： PMC1164754          DOI： 10.1042/bj1640027

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  A micro-autoanalytic procedure developed for the determination of ketone bodies, gluconeogenic amino acids, pyruvate, lactate, and glucose in metabolic studies.

Authors:  P T Ozand; R L Hawkins; R M Collins; J T Tildon; M Cornblath
Journal:  Biochem Med       Date:  1975-10

2.  Intracellular localization of the 3-hydroxy-3-methylglutaryl coenzme A cycle enzymes in liver. Separate cytoplasmic and mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A generating systems for cholesterogenesis and ketogenesis.

Authors:  K D Clinkenbeard; W D Reed; R A Mooney; M D Lane
Journal:  J Biol Chem       Date:  1975-04-25       Impact factor: 5.157

3.  Characterization of the different polypeptide components and analysis of subunit assembly in ferritin.

Authors:  K Ishitani; Y Niitsu; I Listowsky
Journal:  J Biol Chem       Date:  1975-04-25       Impact factor: 5.157

4.  Ketogenesis and cholesterol synthesis in normal and neoplastic tissues of the rat.

Authors:  J D McGarry; D W Foster
Journal:  J Biol Chem       Date:  1969-08-10       Impact factor: 5.157

5.  The acetoacetyl-coenzyme A thiolases of rat brain and their relative activities during postnatal development.

Authors:  B Middleton
Journal:  Biochem J       Date:  1973-04       Impact factor: 3.857

6.  On the mechanism of ketogenesis and its control. I. On a possible role of acetoacetyl-CoA thiolase in the control of ketone body production.

Authors:  W Huth; C Dierich; V von Oeynhausen; W Seubert
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1973-06

7.  Molecular and catalytic properties of cytosolic acetoacetyl coenzyme A thiolase from avian liver.

Authors:  K D Clinkenbeard; T Sugiyama; J Moss; W D Reed; M D Lane
Journal:  J Biol Chem       Date:  1973-04-10       Impact factor: 5.157

8.  Turnover rates of ketone bodies in normal, starved and alloxan-diabetic rats.

Authors:  M W Bates; H A Krebs; D H Williamson
Journal:  Biochem J       Date:  1968-12       Impact factor: 3.857

9.  Ability of exogenous alanine to lower blood beta-hydroxybutyrate during development in rats.

Authors:  P T Ozand; J T Tildon; J H Stevenson; W D Reed; M Cornblath
Journal:  Am J Physiol       Date:  1976-05

10.  Localization of the enzymes of ketogenesis in rat liver mitochondria.

Authors:  M J Chapman; L R Miller; J A Ontko
Journal:  J Cell Biol       Date:  1973-08       Impact factor: 10.539
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  2 in total

1.  Comparative studies of early liver dysfunction in senescence-accelerated mouse using mitochondrial proteomics approaches.

Authors:  Yashu Liu; Jintang He; Shaoyi Ji; Qingsong Wang; Hai Pu; Tingting Jiang; Lingyao Meng; Xiuwei Yang; Jianguo Ji
Journal:  Mol Cell Proteomics       Date:  2008-05-29       Impact factor: 5.911

2.  A double-isotope method for the measurement of ketone-body turnover in the rat. Effect of L-alanine.

Authors:  W D Reed; P J Baab; R L Hawkins; P T Ozand
Journal:  Biochem J       Date:  1984-04-01       Impact factor: 3.857
  2 in total

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