Literature DB >> 181334

A biochemical approach to the study of the transmission of mouse mammary tumor viruses in mouse strains RIII and C3H.

R Michalides, G Vlahakis, J Schlom.   

Abstract

Mouse mammary tumor virus (MMTV) proviral sequences were detected in the cellular DNA of mammary tumors and livers of RIII and C3H mice by molecular hybridization with radioactively labelled MMTV 60-70S RNA or tritiated MMTV complementary DNA (cDNA). By means of DNA:DNA reassociation kinetics, the DNA of the mammary tumor cells of these two mouse strains were found to contain more MMTV proviral sequences than the DNA of liver cells of these same tumor-bearing mice. Evidence is also presented that the DNA of the liver cells lacks a part (approximately 25%) of the MMTV proviral sequences found in the mammary tumor cells of these mouse strains. The relationship of the extra MMTV proviral sequences found in mammary tumor cells to the early mammary tumor-igenesis seen in these mouse strains is discussed.

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Year:  1976        PMID： 181334     DOI： 10.1002/ijc.2910180114

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  14 in total

1.  Identification of the Mtv-2 gene responsible for the early appearance of mammary tumors in the GR mouse by nucleic acid hybridization.

Authors:  R Michalides; L van Deemter; R R Nuss; R van Nie
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

2.  Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains.

Authors:  R Michalides; L van Deemter; R Nusse; G Röpcke; L Boot
Journal:  J Virol       Date:  1978-09       Impact factor: 5.103

3.  Identification and partial characterization of an endogenous form of mouse mammary tumor virus that is transcribed into the virion-associated RNA genome.

Authors:  T G Fanning; J P Puma; R D Cardiff
Journal:  Nucleic Acids Res       Date:  1980-12-11       Impact factor: 16.971

4.  Establishment of a C3Hf mammary tumor cell line expressing endogenous mouse mammary tumor virus: antigenic and genetic relationships of this virus with highly oncogenic mouse mammary tumor viruses.

Authors:  L O Arthur; G G Lovinger; G Schochetman
Journal:  J Virol       Date:  1979-12       Impact factor: 5.103

5.  Selective amplification of mouse mammary tumor virus in mammary tumors of GR mice.

Authors:  T G Fanning; J P Puma; R D Cardiff
Journal:  J Virol       Date:  1980-10       Impact factor: 5.103

6.  Characterization of endogenous and exogenous mouse mammary tumor virus proviral DNA with site-specific molecular clones.

Authors:  B Groner; E Buetti; H Diggelmann; N E Hynes
Journal:  J Virol       Date:  1980-12       Impact factor: 5.103

7.  Isolation of the mouse mammary tumor virus sequences not transmitted as germinal provirus in the C3H and RIII mouse strains.

Authors:  W Drohan; R Kettmann; D Colcher; J Schlom
Journal:  J Virol       Date:  1977-03       Impact factor: 5.103

8.  Methylation and amplification of mouse mammary tumor virus DNA in normal, premalignant, and malignant cells of GR/A mice.

Authors:  T G Fanning; A B Vassos; R D Cardiff
Journal:  J Virol       Date:  1982-03       Impact factor: 5.103

9.  Number and location of mouse mammary tumor virus proviral DNA in mouse DNA of normal tissue and of mammary tumors.

Authors:  B Groner; N E Hynes
Journal:  J Virol       Date:  1980-03       Impact factor: 5.103

10.  Alterations of a mouse mammary tumor virus glycoprotein with interferon treatment.

Authors:  M J Yagi; N W King; J G Bekesi
Journal:  J Virol       Date:  1980-04       Impact factor: 5.103
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