Literature DB >> 1812993

Interleukin-6 production by thyroid epithelial cells. Enhancement by interleukin-1.

M Diamant1, L Kayser, A K Rasmussen, K Bech, U Feldt-Rassmussen.   

Abstract

Interleukin-1 is a potent inhibitor of thyroglobulin and cAMP production in human thyroid cells and the inhibitory effect is enhanced by tumor necrosis factor-alpha and interferon-gamma. In the present study secondary cultures of human thyroid cells produced interleukin-6 and the production was significantly increased after exposure of the cells to recombinant interleukin-1 alpha and -1 beta. This increase was dose-dependent and concomitant of the IL-1 induced decrease in cAMP and thyroglobulin production. Both tumor necrosis factor-alpha and -beta also augmented interleukin-6 production, but less potently than interleukin-1. Interferon-gamma did not affect the production of interleukin-6. The rat thyroid cell line FRTL-5 produced interleukin-6 spontaneously, and the production was enhanced after addition of recombinant interleukin-1 beta. A pathogenetic role of interleukin-6 in autoimmune thyroid disease is suggested.

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Year:  1991        PMID： 1812993     DOI： 10.3109/08916939108994704

Source DB:  PubMed          Journal:  Autoimmunity        ISSN： 0891-6934            Impact factor:   2.815


  8 in total

1.  Thyrotropin modifies activation of nuclear factor kappaB by tumour necrosis factor alpha in rat thyroid cell line.

Authors:  T Kikumori; F Kambe; T Nagaya; H Funahashi; H Seo
Journal:  Biochem J       Date:  2001-03-15       Impact factor: 3.857

2.  Co-expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) in thyroid nodules is associated with co-expression of CD30 ligand/CD30 receptor.

Authors:  R M Ruggeri; D Villari; A Simone; R Scarfi; M Attard; F Orlandi; G Barresi; F Trimarchi; M Trovato; S Benvenga
Journal:  J Endocrinol Invest       Date:  2002-12       Impact factor: 4.256

3.  IL-10 expression in thyroid glands: protective or harmful role against thyroid autoimmunity?

Authors:  J R de la Vega; J C Vilaplana; A Biro; L Hammond; G F Bottazzo; R Mirakian
Journal:  Clin Exp Immunol       Date:  1998-07       Impact factor: 4.330

Review 4.  Influence of phthalates on cytokine production in monocytes and macrophages: a systematic review of experimental trials.

Authors:  Juliana Frohnert Hansen; Klaus Bendtzen; Malene Boas; Hanne Frederiksen; Claus H Nielsen; Åse Krogh Rasmussen; Ulla Feldt-Rasmussen
Journal:  PLoS One       Date:  2015-03-26       Impact factor: 3.240

5.  Phthalates Are Metabolised by Primary Thyroid Cell Cultures but Have Limited Influence on Selected Thyroid Cell Functions In Vitro.

Authors:  Juliana Frohnert Hansen; Marianne Møller Brorson; Malene Boas; Hanne Frederiksen; Claus Henrik Nielsen; Emma Sofie Lindström; Jacob Hofman-Bang; Marie-Louise Hartoft-Nielsen; Thomas Frisch; Katharina M Main; Klaus Bendtzen; Åse Krogh Rasmussen; Ulla Feldt-Rasmussen
Journal:  PLoS One       Date:  2016-03-17       Impact factor: 3.240

6.  The flame retardant DE-71 (a mixture of polybrominated diphenyl ethers) inhibits human differentiated thyroid cell function in vitro.

Authors:  Thit Mynster Kronborg; Juliana Frohnert Hansen; Åse Krogh Rasmussen; Katrin Vorkamp; Claus Henrik Nielsen; Marie Frederiksen; Jacob Hofman-Bang; Christoffer Holst Hahn; Louise Ramhøj; Ulla Feldt-Rasmussen
Journal:  PLoS One       Date:  2017-06-23       Impact factor: 3.240

7.  The cytokines, interleukin-1 beta, interleukin-6 and interferon-gamma upregulate the expression of intercellular adhesion molecule-1(ICAM-1) in rat thyroid cell line, FRTL-5.

Authors:  M Shong; H K Ro; Y K Kim; C J Yoo; J H Lee; C U Song; B Y Cho
Journal:  Korean J Intern Med       Date:  1994-07       Impact factor: 2.884

8.  Aberrant MRP14 expression in thyroid follicular cells mediates chemokine secretion through the IL-1β/MAPK pathway in Hashimoto's thyroiditis.

Authors:  Xuan Luo; Tingting Zheng; Chaoming Mao; Xin Dong; Xiao Mou; Chengcheng Xu; Qingyan Lu; Baocui Liu; Shengjun Wang; Yichuan Xiao
Journal:  Endocr Connect       Date:  2018-05-15       Impact factor: 3.335
  8 in total

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