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Literature DB >> 18116

Bucolome in prevention of hyperbilirubinaemia in preterm infants.

Abstract

Fifty preterm babies were randomly assigned to a group given oral bucolome (30 mg/kg per day for 5 days) and a control group. Serum bilirubin levels of the treated infants from day 4 onwards were consistently lower than those of the control infants. 3 of the 25 control infants (but none of the 25 treated infants) had bilirubin levels greater than 18 mg/100 ml (308 mumol/l) and required exchange transfusion. No sedation or drowsiness was observed in the infants given bucolome, and though the drug caused some vomiting, weight gains were unaffected.

Entities: Chemical Disease Species

Mesh：

Substances：
Barbiturates

Year: 1977 PMID： 18116 PMCID： PMC1544764 DOI： 10.1136/adc.52.7.549

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

4 in total

1. [1-Cyclohexyl-5-butylbarbituric acid in the treatment of neonatal hyperbilirubinemia].

Authors: R Gavinelli; M Gallenca; G P Grasso
Journal: Minerva Pediatr Date: 1976-04-28 Impact factor: 1.312

2. Familial nonhemolytic jaundice with late onset of neurological damage.

Authors: S D Blumenschein; R J Kallen; B Storey; J C Natzschka; G B Odell; B Childs
Journal: Pediatrics Date: 1968-11 Impact factor: 7.124

3. [Use of 5-butyl-1-cyclohexyl-2,4,6,-trioxoperidropyrimidine (BCP) in the prevention and therapy of neonatal hyperbilirubinemia. Comparative study with phenobarbital].

Authors: A Centa; G Camera; A Piccinini; P De Pietro; C Tomatis
Journal: Minerva Pediatr Date: 1976-04-28 Impact factor: 1.312

4. [Pharmacological studies on 5-n-butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine (BCP) as an anti-inflammatory agent].

Authors: H Fujimura; A Tsurumi; M Hayashi; M Ushijima; S Esaki
Journal: Nihon Yakurigaku Zasshi Date: 1967-03-20

4 in total

4. Effects of bucolome and related barbiturate derivatives on the displacement of bilirubin from plasma albumin in vivo and in vitro.

Authors: T Yamamoto; Y Adachi; I Kuwahara
Journal: Gastroenterol Jpn Date: 1979-10

4 in total

Bucolome in prevention of hyperbilirubinaemia in preterm infants.

1. [1-Cyclohexyl-5-butylbarbituric acid in the treatment of neonatal hyperbilirubinemia].

2. Familial nonhemolytic jaundice with late onset of neurological damage.

3. [Use of 5-butyl-1-cyclohexyl-2,4,6,-trioxoperidropyrimidine (BCP) in the prevention and therapy of neonatal hyperbilirubinemia. Comparative study with phenobarbital].

4. [Pharmacological studies on 5-n-butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine (BCP) as an anti-inflammatory agent].

1. Effect of bucolome in preterm infants.

2. Danger of bucolome in infants with hyperbilirubinaemia. Experimental evidence.

3. The influence of barbiturate derivatives on the serum bilirubin of the Gunn rat.

4. Effects of bucolome and related barbiturate derivatives on the displacement of bilirubin from plasma albumin in vivo and in vitro.