Literature DB >> 1810961

Solid-phase extraction of midazolam and two of its metabolites from plasma for high-performance liquid chromatographic analysis.

V Sautou1, J Chopineau, M P Terrisse, P Bastide.   

Abstract

A rapid, sensitive and selective assay of midazolam and two of its metabolites in plasma, based on high-performance liquid chromatography, has been developed. The compounds are subjected to solid-phase extraction, using C18 cartridges (Bond-Elut). Recoveries are in excess of 90% for midazolam and its metabolites. The limit of quantitation of the assay is 50 ng/ml of plasma for each compound.

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Year:  1991        PMID: 1810961     DOI: 10.1016/0378-4347(91)80459-p

Source DB:  PubMed          Journal:  J Chromatogr


  4 in total

1.  In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes.

Authors:  Bill J Gurley; Stephanie F Gardner; Martha A Hubbard; D Keith Williams; W Brooks Gentry; Ikhlas A Khan; Amit Shah
Journal:  Clin Pharmacol Ther       Date:  2005-05       Impact factor: 6.875

2.  Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba.

Authors:  Bill J Gurley; Stephanie F Gardner; Martha A Hubbard; D Keith Williams; W Brooks Gentry; Yanyan Cui; Catharina Y W Ang
Journal:  Drugs Aging       Date:  2005       Impact factor: 3.923

3.  Lack of sex-related differences in saquinavir pharmacokinetics in an HIV-seronegative cohort.

Authors:  Sarah M Robertson; Elizabeth Formentini; Raul M Alfaro; Ven Natarajan; Judith Falloon; Scott R Penzak
Journal:  Br J Clin Pharmacol       Date:  2006-04       Impact factor: 4.335

4.  Effects of Garlic on Cytochromes P450 2C9- and 3A4-Mediated Drug Metabolism in Human Hepatocytes.

Authors:  Beatrice E Ho; Danny D Shen; Jeannine S McCune; Tot Bui; Linda Risler; Ziping Yang; Rodney J Y Ho
Journal:  Sci Pharm       Date:  2010-06-09
  4 in total

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