| Literature DB >> 1810454 |
E C De Boer1, W H De Jong, P A Steerenberg, A P Van der Meijden, L A Aarden, F M Debruyne, E J Ruitenberg.
Abstract
The urine of superficial bladder cancer patients treated intravesically with BCG was examined for the presence of leukocytes and cytokines. The number of leukocytes was markedly increased 24h and 48h after five or more BCG instillations. Flow cytofluorometric analysis revealed that, in addition to large numbers of granulocytes, monocytes/macrophages and T-lymphocytes were clearly detectable. The T cells were predominantly CD4+ and probably activated, since they expressed IL2 receptors and HLA-DR. The cytokines IL1, IL2, IL6 and TNF alpha were also increased after BCG instillations. These cytokines and leukocytes may play a role in the antitumor activity of BCG.Entities:
Mesh：
Substances：
Year: 1991 PMID： 1810454
Source DB: PubMed Journal: In Vivo ISSN： 0258-851X Impact factor: 2.155