Literature DB >> 1810426

Prophylactic anti-tumor effect of Hochu-ekki-to (TJ41) by enhancing natural killer cell activity.

J M Cho1, N Sato, K Kikuchi.   

Abstract

We assessed the anti-tumor activity in vivo of a kampo (Chinese) prescription Hocku-ekki-to (TJ41) in the rat and mouse tumor model. The growth of tumors was clearly inhibited in syngeneic animals given TJ-41 prophylactically. The splenic NK cells of TJ-41-treated WKA rats showed enhanced cytotoxicity against tumors including NK-sensitive YAC-1 targets. TJ-41 did not increase the splenic NK cell population, but it appeared that TJ-41 could potentiate the cytotoxic capability of each NK cell. These data indicate that TJ-41 may be useful for prophylactic immunotherapy of cancer. One of the mechanisms of the potent inhibitory effect by TJ-41 on tumor growth might be explained by its enhancement of NK activity.

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Year:  1991        PMID： 1810426

Source DB:  PubMed          Journal:  In Vivo        ISSN： 0258-851X            Impact factor:   2.155


  9 in total

1.  Preventive effect of a traditional herbal medicine, Hochu-ekki-to, on immunosuppression induced by surgical stress.

Authors:  Motohide Kimura; Tetsuro Sasada; Michiyuki Kanai; Yasuhiro Kawai; Yuka Yoshida; Eriko Hayashi; Shingo Iwata; Arimichi Takabayashi
Journal:  Surg Today       Date:  2008-03-27       Impact factor: 2.549

2.  Effect of hochuekkito on alveolar macrophage inflammatory responses in hyperglycemic mice.

Authors:  Masayuki Nakayama; Yukihiko Sugiyama; Hideaki Yamasawa; Manabu Soda; Naoko Mato; Tatsuya Hosono; Masashi Bando
Journal:  Inflammation       Date:  2012-08       Impact factor: 4.092

3.  Stimulating effect of Japanese herbal (kampo) medicine, hochuekkito on upper respiratory mucosal immune system.

Authors:  H Kiyohara; T Nagai; K Munakata; K Nonaka; T Hanawa; S J Kim; H Yamada
Journal:  Evid Based Complement Alternat Med       Date:  2006-06-24       Impact factor: 2.629

4.  Immunoglobulin G4-Related Retroperitoneal Fibrosis Treated with Hochuekkito, a Kampo Medicine, following Steroid Treatment.

Authors:  Minoru Fukuchi; Shinji Sakurai; Toshiaki Kogure; Hiroshi Naitoh; Hiroyuki Kuwano
Journal:  Case Rep Gastroenterol       Date:  2014-05-28

5.  Hochuekkito, a Kampo (Traditional Japanese Herbal) Medicine, and its Polysaccharide Portion Stimulate G-CSF Secretion from Intestinal Epithelial Cells.

Authors:  Tsukasa Matsumoto; Michiyo Moriya; Hiroaki Kiyohara; Yoshiaki Tabuchi; Haruki Yamada
Journal:  Evid Based Complement Alternat Med       Date:  2008-02-27       Impact factor: 2.629

6.  Hochuekkito, a Kampo (traditional Japanese herbal) Medicine, Enhances Mucosal IgA Antibody Response in Mice Immunized with Antigen-entrapped Biodegradable Microparticles.

Authors:  Tsukasa Matsumoto; Masaaki Noguchi; Osamu Hayashi; Kimiko Makino; Haruki Yamada
Journal:  Evid Based Complement Alternat Med       Date:  2007-10-29       Impact factor: 2.629

7.  Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome.

Authors:  Xin Q Wang; Takashi Takahashi; Shi-Jie Zhu; Junji Moriya; Seiichiro Saegusa; Jun'ichi Yamakawa; Kazuya Kusaka; Tohru Itoh; Tsugiyasu Kanda
Journal:  Evid Based Complement Alternat Med       Date:  2004-09-01       Impact factor: 2.629

Review 8.  The translational aspect of complementary and alternative medicine for cancer with particular emphasis on Kampo.

Authors:  Marie Amitani; Haruka Amitani; Robert A Sloan; Hajime Suzuki; Nanami Sameshima; Akihiro Asakawa; Yasuhito Nerome; Tetsuhiro Owaki; Akio Inui; Etsuo Hoshino
Journal:  Front Pharmacol       Date:  2015-08-06       Impact factor: 5.810

9.  Immunological efficacy of herbal medicines in prostate cancer patients treated by personalized peptide vaccine.

Authors:  Noriko Koga; Fukuko Moriya; Kayoko Waki; Akira Yamada; Kyogo Itoh; Masanori Noguchi
Journal:  Cancer Sci       Date:  2017-10-03       Impact factor: 6.716
  9 in total

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