BACKGROUND: We evaluated the effectiveness of intraarterial methotrexate infusion as a primary therapy for oral verrucous carcinoma (VC). METHODS: Fifteen male patients (mean age, 55 years) were included. By using an implantable port-catheter system and a portable pump, methotrexate was continuously infused to the external carotid artery for a mean period of 7.5 days (50 mg/day), followed by weekly bolus of methotrexate (25 mg) via intraarterial route for a mean period of 10 weeks. RESULTS: The tumor regressed dramatically and disappeared completely after treatment within a mean period of 2.5 months. All patients obtained complete remission and recovered without disfigurement. All patients were alive without disease recurrence at a median follow-up of 43 months. The side effects were tolerable. CONCLUSIONS: The results of our treatment modality for oral VC appear to compete favorably with the results of surgical series and even more with those of radiotherapy series.
BACKGROUND: We evaluated the effectiveness of intraarterial methotrexate infusion as a primary therapy for oral verrucous carcinoma (VC). METHODS: Fifteen male patients (mean age, 55 years) were included. By using an implantable port-catheter system and a portable pump, methotrexate was continuously infused to the external carotid artery for a mean period of 7.5 days (50 mg/day), followed by weekly bolus of methotrexate (25 mg) via intraarterial route for a mean period of 10 weeks. RESULTS: The tumor regressed dramatically and disappeared completely after treatment within a mean period of 2.5 months. All patients obtained complete remission and recovered without disfigurement. All patients were alive without disease recurrence at a median follow-up of 43 months. The side effects were tolerable. CONCLUSIONS: The results of our treatment modality for oral VC appear to compete favorably with the results of surgical series and even more with those of radiotherapy series.
Authors: Fernando López; Michelle D Williams; Antonio Cardesa; Jennifer L Hunt; Primož Strojan; Alessandra Rinaldo; Iain J Nixon; Juan P Rodrigo; Nabil F Saba; William M Mendenhall; Miquel Quer; Carlos Suárez; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2017-03-31 Impact factor: 2.503
Authors: C-W Tsai; F J Lai; H M Sheu; Y S Lin; T H Chang; M S Jan; S M Chen; P C Hsu; T T Huang; T C Huang; M C Sheen; S T Chen; W C Chang; N S Chang; L J Hsu Journal: Cell Death Dis Date: 2013-09-05 Impact factor: 8.469