Literature DB >> 18097759

Aging-related changes in the expression of apoptosis-associated molecules in neurosecretory cells of the mouse hypothalamus.

E D Bazhanova1, V N Molodtsov, K I Pavlov.   

Abstract

The aim of the present work was to identify the characteristics of the control of apoptosis in neurosecretory centers of aged (18 months) mice on exposure to the immunomodulator interferon-alpha (IA) in comparison with young (two months) mice. Age-related activation of apoptosis in the supraoptic (SON) and paraventricular (PVN) nuclei was found to be mediated by different pathways and could result from changes in the ratio of synthesis of pro-(Bax) and antiapoptotic (Mcl-1, Bcl-2) molecules. In addition, the apoptosis signal cascade in young mice treated with IA was identical in both nuclei, while in aged mice there were differences between the SON and the PVN.

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Year:  2008        PMID： 18097759     DOI： 10.1007/s11055-008-0006-2

Source DB:  PubMed          Journal:  Neurosci Behav Physiol        ISSN： 0097-0549


  17 in total

1.  [Effect of interferon-alpha on the hypothalamo-hypophyseal system and the pituitary-adrenal system of mice during aging].

Authors:  E D Bazhanova; D L Telyĭ
Journal:  Zh Evol Biokhim Fiziol       Date:  2003 Sep-Oct

2.  Apoptosis related antigen, Le(Y) and nick-end labeling are positive in spinal motor neurons in amyotrophic lateral sclerosis.

Authors:  Y Yoshiyama; T Yamada; K Asanuma; T Asahi
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088

3.  Oxidative-stress-dependent up-regulation of Bcl-2 expression in the central nervous system of aged Fisher-344 rats.

Authors:  J A Kaufmann; P C Bickford; G Taglialatela
Journal:  J Neurochem       Date:  2001-02       Impact factor: 5.372

4.  Age-related changes of apoptotic cell death in human lymphocytes.

Authors:  K Schindowski; S Leutner; W E Müller; A Eckert
Journal:  Neurobiol Aging       Date:  2000 Sep-Oct       Impact factor: 4.673

5.  Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice.

Authors:  K I Andreasson; A Savonenko; S Vidensky; J J Goellner; Y Zhang; A Shaffer; W E Kaufmann; P F Worley; P Isakson; A L Markowska
Journal:  J Neurosci       Date:  2001-10-15       Impact factor: 6.167

6.  Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1.

Authors:  M Jourdan; J De Vos; N Mechti; B Klein
Journal:  Cell Death Differ       Date:  2000-12       Impact factor: 15.828

Review 7.  The role of apoptosis in the normal aging brain, skeletal muscle, and heart.

Authors:  Michael Pollack; Sharon Phaneuf; Amie Dirks; Christiaan Leeuwenburgh
Journal:  Ann N Y Acad Sci       Date:  2002-04       Impact factor: 5.691

8.  Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs.

Authors:  Yingpei Zhang; Elizabeth Chong; Brian Herman
Journal:  Exp Gerontol       Date:  2002-06       Impact factor: 4.032

9.  Interferon alpha extends the survival of human myeloma cells through an upregulation of the Mcl-1 anti-apoptotic molecule.

Authors:  D Puthier; W Thabard; M Rapp; M Etrillard; J Harousseau; R Bataille; M Amiot
Journal:  Br J Haematol       Date:  2001-02       Impact factor: 6.998

10.  Glutamate mediates cell death and increases the Bax to Bcl-2 ratio in a differentiated neuronal cell line.

Authors:  William R Schelman; Robert D Andres; Kimberly J Sipe; Evan Kang; James A Weyhenmeyer
Journal:  Brain Res Mol Brain Res       Date:  2004-09-28
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