| Literature DB >> 18097733 |
Kazuaki Miyake1, Yukio Horikawa2,3, Kazuo Hara4, Kazuki Yasuda5, Haruhiko Osawa6, Hiroto Furuta7, Yushi Hirota1, Kazuya Yamagata8, Yoshinori Hinokio9, Yoshitomo Oka9, Naoko Iwasaki10, Yasuhiko Iwamoto10, Yuichiro Yamada11,12, Yutaka Seino13,12, Hiroshi Maegawa14, Atsunori Kashiwagi14, Ken Yamamoto15, Katsushi Tokunaga16, Jun Takeda2, Hideichi Makino6, Kishio Nanjo7, Takashi Kadowaki4, Masato Kasuga17.
Abstract
Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747-751, 2007) and Hayashi et al. (Diabetologia 50:980-984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR=1.48, P=2.7 x 10(-4); OR=1.39, P=4.6 x 10(-4); OR=1.70, P=9.8 x 10(-5), respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.Entities:
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Year: 2007 PMID： 18097733 DOI： 10.1007/s10038-007-0231-5
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172