I-Nae Park1, Jin-Sook Ryu, Tae Sun Shim. 1. Division of Pulmonology and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Songpa-Gu, Seoul, Korea.
Abstract
BACKGROUND: Monitoring the response to antituberculosis (anti-TB) treatment can be difficult in patients with tuberculoma. We have retrospectively assessed the ability of F-18 fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) to evaluate the response to anti-TB treatment in patients with tuberculoma. METHODS: Two patients with tuberculoma underwent repeat PET scans during anti-TB treatment. Changes in maximal standard uptake value (SUV) of the tuberculoma on PET images were analyzed between 2 scans. Initial PET scans were performed before the start of anti-TB treatment (T0), and later scans were performed after completion of treatment (T1). RESULTS: In a 57-year-old female patient with clinical TB, maximal SUV of tuberculoma on PET scan decreased from 2.6 (at T0) to an undetectable value (at T1) at an interval of 187 days. In a 60-year-old woman with biopsy-proven TB, maximal SUV of tuberculoma on PET scan decreased from 4.8 (at T0) to 1.1 (at T1) at an interval of 192 days. CONCLUSION: PET scans may be useful for monitoring responses to anti-TB treatment in patients with tuberculoma.
BACKGROUND: Monitoring the response to antituberculosis (anti-TB) treatment can be difficult in patients with tuberculoma. We have retrospectively assessed the ability of F-18 fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) to evaluate the response to anti-TB treatment in patients with tuberculoma. METHODS: Two patients with tuberculoma underwent repeat PET scans during anti-TB treatment. Changes in maximal standard uptake value (SUV) of the tuberculoma on PET images were analyzed between 2 scans. Initial PET scans were performed before the start of anti-TB treatment (T0), and later scans were performed after completion of treatment (T1). RESULTS: In a 57-year-old female patient with clinical TB, maximal SUV of tuberculoma on PET scan decreased from 2.6 (at T0) to an undetectable value (at T1) at an interval of 187 days. In a 60-year-old woman with biopsy-proven TB, maximal SUV of tuberculoma on PET scan decreased from 4.8 (at T0) to 1.1 (at T1) at an interval of 192 days. CONCLUSION: PET scans may be useful for monitoring responses to anti-TB treatment in patients with tuberculoma.
Authors: Stephanie L Davis; Eric L Nuermberger; Peter K Um; Camille Vidal; Bruno Jedynak; Martin G Pomper; William R Bishai; Sanjay K Jain Journal: Antimicrob Agents Chemother Date: 2009-09-08 Impact factor: 5.191
Authors: Yong Hyun Park; Chang Min Yu; Eun Sil Kim; Jun Oh Jung; Han Seok Seo; Ju Hyoung Lee; So Chong Hur; So Yeon Kim; Hyon Young Lee Journal: Nucl Med Mol Imaging Date: 2011-11-10
Authors: Ray Y Chen; Lori E Dodd; Myungsun Lee; Praveen Paripati; Dima A Hammoud; James M Mountz; Doosoo Jeon; Nadeem Zia; Homeira Zahiri; M Teresa Coleman; Matthew W Carroll; Jong Doo Lee; Yeon Joo Jeong; Peter Herscovitch; Saher Lahouar; Michael Tartakovsky; Alexander Rosenthal; Sandeep Somaiyya; Soyoung Lee; Lisa C Goldfeder; Ying Cai; Laura E Via; Seung-Kyu Park; Sang-Nae Cho; Clifton E Barry Journal: Sci Transl Med Date: 2014-12-03 Impact factor: 17.956
Authors: Yong Yang; Kathleen Kulka; Ronald C Montelaro; Todd A Reinhart; James Sissons; Alan Aderem; Anil K Ojha Journal: Cell Host Microbe Date: 2014-02-12 Impact factor: 21.023
Authors: Daniel H Johnson; Laura E Via; Peter Kim; Dominick Laddy; Chuen-Yen Lau; Edward A Weinstein; Sanjay Jain Journal: Nucl Med Biol Date: 2014-08-07 Impact factor: 2.408
Authors: Clifton E Barry; Helena I Boshoff; Véronique Dartois; Thomas Dick; Sabine Ehrt; JoAnne Flynn; Dirk Schnappinger; Robert J Wilkinson; Douglas Young Journal: Nat Rev Microbiol Date: 2009-10-26 Impact factor: 60.633