| Literature DB >> 18097235 |
Daniela Bezemer1, Ard van Sighem, Frank de Wolf, Marion Cornelissen, Antoinette C van der Kuyl, Suzanne Jurriaans, Lia van der Hoek, Maria Prins, Roel A Coutinho, Vladimir V Lukashov.
Abstract
In addition to development or selection of resistance, failure to continuously suppress HIV-1 production while still using initially effective combination antiretroviral therapy (cART) may result from super-infection with a drug-resistant strain. Both transmission of drug resistant HIV and super-infection have been demonstrated. We analysed HIV pol genes obtained before start of initially successful cART and during failure while still on cART in 101 patients. Difference in precART and cART failure sequences were explained by evolution and not by super-infection.Entities:
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Year: 2008 PMID: 18097235 DOI: 10.1097/QAD.0b013e3282f37489
Source DB: PubMed Journal: AIDS ISSN: 0269-9370 Impact factor: 4.177