Literature DB >> 18096497

2-AG + 2 new players = forecast for therapeutic advances.

William Marrs1, Nephi Stella.   

Abstract

In this issue of Chemistry & Biology, Blankman et al. identify new enzymes hydrolyzing the endocannabionoid 2-arachidonoyl glycerol (2-AG), increasing the complexity of endocannabinoid signaling in the brain, but also pinpointing additional therapeutic targets.

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Year:  2007        PMID： 18096497     DOI： 10.1016/j.chembiol.2007.12.004

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  7 in total

Review 1.  Cannabis use during pregnancy: Pharmacokinetics and effects on child development.

Authors:  Kimberly S Grant; Rebekah Petroff; Nina Isoherranen; Nephi Stella; Thomas M Burbacher
Journal:  Pharmacol Ther       Date:  2017-08-25       Impact factor: 12.310

2.  Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

Authors:  William R Marrs; Eric A Horne; Silvia Ortega-Gutierrez; Jose Antonio Cisneros; Cong Xu; Yi Hsing Lin; Giulio G Muccioli; Maria L Lopez-Rodriguez; Nephi Stella
Journal:  J Biol Chem       Date:  2011-06-10       Impact factor: 5.157

3.  The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.

Authors:  William R Marrs; Jacqueline L Blankman; Eric A Horne; Aurore Thomazeau; Yi Hsing Lin; Jonathan Coy; Agnes L Bodor; Giulio G Muccioli; Sherry Shu-Jung Hu; Grace Woodruff; Susan Fung; Mathieu Lafourcade; Jessica P Alexander; Jonathan Z Long; Weiwei Li; Cong Xu; Thomas Möller; Ken Mackie; Olivier J Manzoni; Benjamin F Cravatt; Nephi Stella
Journal:  Nat Neurosci       Date:  2010-07-25       Impact factor: 24.884

4.  Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism.

Authors:  Torunn Fiskerstrand; Dorra H'mida-Ben Brahim; Stefan Johansson; Abderrahim M'zahem; Bjørn Ivar Haukanes; Nathalie Drouot; Julian Zimmermann; Andrew J Cole; Christian Vedeler; Cecilie Bredrup; Mirna Assoum; Meriem Tazir; Thomas Klockgether; Abdelmadjid Hamri; Vidar M Steen; Helge Boman; Laurence A Bindoff; Michel Koenig; Per M Knappskog
Journal:  Am J Hum Genet       Date:  2010-09-10       Impact factor: 11.025

Review 5.  Measuring endocannabinoid hydrolysis: refining our tools and understanding.

Authors:  William Marrs; Nephi Stella
Journal:  AAPS J       Date:  2009-05-08       Impact factor: 4.009

Review 6.  Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling.

Authors:  Alexis L Franks; Kimberly J Berry; Donald B DeFranco
Journal:  J Neuroendocrinol       Date:  2019-10-02       Impact factor: 3.870

7.  Adipose ABHD6 regulates tolerance to cold and thermogenic programs.

Authors:  Pegah Poursharifi; Camille Attané; Yves Mugabo; Anfal Al-Mass; Anindya Ghosh; Clémence Schmitt; Shangang Zhao; Julian Guida; Roxane Lussier; Heidi Erb; Isabelle Chenier; Marie-Line Peyot; Erik Joly; Christophe Noll; André C Carpentier; S R Murthy Madiraju; Marc Prentki
Journal:  JCI Insight       Date:  2020-12-17
  7 in total

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