AIMS: Our aim was to demonstrate that functional gold nanoparticles can be used as photothermal agents for the selective killing of pathogenic bacteria. MATERIALS & METHODS: Gold nanoparticles with polygonal shapes, capable of absorbing near infrared (NIR) light, were generated through a photochemical reaction. Vancomycin, which can bind with the terminal D-Ala-D-Ala moieties of the peptide units of pathogen cell walls, was immobilized on the surface of the gold nanoparticles. The vancomycin-bound gold nanoparticles were used as the photothermal agents for the inhibition of pathogenic bacteria growth, under irradiation of NIR light (808 nm). RESULTS & DISCUSSION: We have demonstrated that vancomycin-bound gold nanoparticles are capable of selective-binding onto the cell walls of pathogenic bacteria. A large portion (>99%) of bacteria targeted by the gold nanoparticles was destroyed under illumination by NIR light within 5 min owing to suffering from heating. CONCLUSIONS: This photothermal approach is effective for the inhibition of pathogenic bacteria cell growth, including Gram-positive bacteria, Gram-negative bacteria and antibiotic-resistant bacteria.
AIMS: Our aim was to demonstrate that functional gold nanoparticles can be used as photothermal agents for the selective killing of pathogenic bacteria. MATERIALS & METHODS: Gold nanoparticles with polygonal shapes, capable of absorbing near infrared (NIR) light, were generated through a photochemical reaction. Vancomycin, which can bind with the terminal D-Ala-D-Ala moieties of the peptide units of pathogen cell walls, was immobilized on the surface of the gold nanoparticles. The vancomycin-bound gold nanoparticles were used as the photothermal agents for the inhibition of pathogenic bacteria growth, under irradiation of NIR light (808 nm). RESULTS & DISCUSSION: We have demonstrated that vancomycin-bound gold nanoparticles are capable of selective-binding onto the cell walls of pathogenic bacteria. A large portion (>99%) of bacteria targeted by the gold nanoparticles was destroyed under illumination by NIR light within 5 min owing to suffering from heating. CONCLUSIONS: This photothermal approach is effective for the inhibition of pathogenic bacteria cell growth, including Gram-positive bacteria, Gram-negative bacteria and antibiotic-resistant bacteria.
Authors: Hu Tao; Jana M Kainerstorfer; Sean M Siebert; Eleanor M Pritchard; Angelo Sassaroli; Bruce J B Panilaitis; Mark A Brenckle; Jason J Amsden; Jonathan Levitt; Sergio Fantini; David L Kaplan; Fiorenzo G Omenetto Journal: Proc Natl Acad Sci U S A Date: 2012-11-12 Impact factor: 11.205
Authors: G L Burygin; B N Khlebtsov; A N Shantrokha; L A Dykman; V A Bogatyrev; N G Khlebtsov Journal: Nanoscale Res Lett Date: 2009-04-21 Impact factor: 4.703
Authors: Vivek D Badwaik; Lakshmisri M Vangala; Dillon S Pender; Chad B Willis; Zoraida P Aguilar; Matthew S Gonzalez; Rammohan Paripelly; Rajalingam Dakshinamurthy Journal: Nanoscale Res Lett Date: 2012-11-12 Impact factor: 4.703