Jin Wu1, Zheng Wang, Dong Wang. 1. Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Abstract
OBJECTIVE: To explore the relationship between respiratory virus infection and the episode of steroid responsive simple nephrotic syndrome (SRSNS). METHODS: Thirty eight children with SRSNS were recruited (28 in the active stage, 10 in the remission stage). Sixty four children (18 with nephritic nephrosis, 16 with bronchiolitis, 15 with secondary glomerular diseases and 15 without diagnosed diseases) served as controls. Reverse transcriptase-PCR (RT-PCR) and alkaline phosphoesterase-anti alkaline phosphoesterase enzyme-linked assay (APAAP) were employed to detect the viral genes and antigens in the urines respectively. The viral antigens in the renal tissues of two children with active SRSNS were also examined by APAAP. RESULTS: The viruses were more often detected in the urines of children with active SRSNS than those with remission SRSNS and the controls. The respiratory syncytial virus (RSV) was the most common virus detected in the urines of children with active SRSNS. The appearance of the viruses gene and antigens was not influenced by the use of steroid. The same antigens were found in the renal tissues of the two children with active SRSNS. CONCLUSION: Respiratory tract viruses may play an important role of triggering the SRSNS.
OBJECTIVE: To explore the relationship between respiratory virus infection and the episode of steroid responsive simple nephrotic syndrome (SRSNS). METHODS: Thirty eight children with SRSNS were recruited (28 in the active stage, 10 in the remission stage). Sixty four children (18 with nephritic nephrosis, 16 with bronchiolitis, 15 with secondary glomerular diseases and 15 without diagnosed diseases) served as controls. Reverse transcriptase-PCR (RT-PCR) and alkaline phosphoesterase-anti alkaline phosphoesterase enzyme-linked assay (APAAP) were employed to detect the viral genes and antigens in the urines respectively. The viral antigens in the renal tissues of two children with active SRSNS were also examined by APAAP. RESULTS: The viruses were more often detected in the urines of children with active SRSNS than those with remission SRSNS and the controls. The respiratory syncytial virus (RSV) was the most common virus detected in the urines of children with active SRSNS. The appearance of the viruses gene and antigens was not influenced by the use of steroid. The same antigens were found in the renal tissues of the two children with active SRSNS. CONCLUSION:Respiratory tract viruses may play an important role of triggering the SRSNS.
Authors: Karen Bohmwald; Janyra A Espinoza; Emma Rey-Jurado; Roberto S Gómez; Pablo A González; Susan M Bueno; Claudia A Riedel; Alexis M Kalergis Journal: Semin Respir Crit Care Med Date: 2016-08-03 Impact factor: 3.119