| Literature DB >> 18095015 |
Eleni Mylona1, Styliani Golfinopoulou, Michael Samarkos, Panagiotis Fanourgiakis, Vasilios Papadakos, Athanasios Skoutelis.
Abstract
Adult onset Still's disease (AOSD) is a well-recognized clinical disorder characterized by involvement of various organs, including liver. However, acute hepatitis or hepatic failure is extremely rare, and most of the reported cases occurred during treatment with hepatotoxic drugs. Anakinra is an interleukin-1 receptor antagonist (IL-1Ra). Experimental and clinical data support a central role for IL-1Ra in fulminant hepatic failure. We report the case of a patient with AOSD complicated with acute hepatitis during treatment with corticosteroids, which was dramatically improved with anakinra.Entities:
Mesh:
Substances:
Year: 2007 PMID: 18095015 DOI: 10.1007/s10067-007-0791-y
Source DB: PubMed Journal: Clin Rheumatol ISSN: 0770-3198 Impact factor: 3.650