Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 IRF-3-dependent and augmented target genes during viral infection.

Literature DB >> 18094709

IRF-3-dependent and augmented target genes during viral infection.

J Andersen¹, S VanScoy, T-F Cheng, D Gomez, N C Reich.

Abstract

Activation of the transcription factor interferon regulatory factor-3 (IRF-3) is an essential event in the innate immune response to viral infection. To understand the contribution of IRF-3 to host defense, we used a systems biology approach to analyze global gene expression dependent on IRF-3. Comparison of expression profiles in cells from IRF-3 knockout animals or wild-type siblings following viral infection revealed three sets of induced genes, those that are strictly dependent on IRF-3, augmented with IRF-3, or not responsive to IRF-3. Products of identified IRF-3 target genes are involved in innate or acquired immunity, or in the regulation of cell cycle, apoptosis and proliferation. These results reveal the global effects of one transcription factor in the immune response and provide information to evaluate the integrated response to viral infection.

Entities: Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 18094709 DOI： 10.1038/sj.gene.6364449

Source DB: PubMed Journal: Genes Immun ISSN： 1466-4879 Impact factor: 2.676

Keyword Cloud
Cited

63 in total

1. A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses.

Authors: Andreas Neerincx; Katja Lautz; Maureen Menning; Elisabeth Kremmer; Paola Zigrino; Marianna Hösel; Hildegard Büning; Robert Schwarzenbacher; Thomas A Kufer
Journal: J Biol Chem Date: 2010-06-10 Impact factor: 5.157

2. Δγ₁134.5 herpes simplex viruses encoding human cytomegalovirus IRS1 or TRS1 induce interferon regulatory factor 3 phosphorylation and an interferon-stimulated gene response.

Authors: Kevin A Cassady; Ute Saunders; Masako Shimamura
Journal: J Virol Date: 2011-11-09 Impact factor: 5.103

3. Type 1 IFN-independent activation of a subset of interferon stimulated genes in West Nile virus Eg101-infected mouse cells.

Authors: Joanna A Pulit-Penaloza; Svetlana V Scherbik; Margo A Brinton
Journal: Virology Date: 2012-02-03 Impact factor: 3.616

4. Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.

Authors: Joanna A Pulit-Penaloza; Svetlana V Scherbik; Margo A Brinton
Journal: Virology Date: 2012-02-03 Impact factor: 3.616

IRF-3-dependent and augmented target genes during viral infection.

1. A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses.

2. Δγ₁134.5 herpes simplex viruses encoding human cytomegalovirus IRS1 or TRS1 induce interferon regulatory factor 3 phosphorylation and an interferon-stimulated gene response.

3. Type 1 IFN-independent activation of a subset of interferon stimulated genes in West Nile virus Eg101-infected mouse cells.

4. Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.

5. The DNA damage response induces IFN.

Review 6. Innate antiviral immune signaling, viral evasion and modulation by HIV-1.

Review 7. Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy.

8. Differential modification of interferon regulatory factor 3 following virus particle entry.

9. The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery.

10. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.