Literature DB >> 18094539

Comparative role of antibiotic and proton pump inhibitor in experimental Clostridium difficile infection in mice.

Sukhminderjit Kaur1, Chetana Vaishnavi, Kaushal Kishore Prasad, Pallab Ray, Rakesh Kochhar.   

Abstract

Clostridium difficile inoculated BALB/c mice were investigated to assess the comparative role of antibiotic and proton pump inhibitor. They were examined for colonization and toxin production by C. difficile as well as myeloperoxidase activity and histopathological changes in the intestinal tract. The C. difficile count, toxin A and B titres and myeloperoxidase activity were significantly higher (P>0.05) in ampicillin and lansoprazole receiving groups as compared to the control and the C. difficile receiving groups. Similarly they showed significant difference (P >0.05) for epithelial damage, oedema and neutrophilic infiltrate in colons. In addition to antibiotic, PPI also acts as an independent risk factor for C. difficile infection in experimental studies.

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Year:  2007        PMID： 18094539     DOI： 10.1111/j.1348-0421.2007.tb04016.x

Source DB:  PubMed          Journal:  Microbiol Immunol        ISSN： 0385-5600            Impact factor:   1.955


  13 in total

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9.  Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis.

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