Literature DB >> 18094140

Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis.

Andrea Gori1, Camilla Tincati, Giuliano Rizzardini, Carlo Torti, Tiziana Quirino, Monique Haarman, Kaouther Ben Amor, Jacqueline van Schaik, Aldwin Vriesema, Jan Knol, Giulia Marchetti, Gjalt Welling, Mario Clerici.   

Abstract

Our results show that impairment of the gastrointestinal tracts in human immunodeficiency virus (HIV)-positive patients is present in the early phases of HIV disease. This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis.

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Year:  2007        PMID： 18094140      PMCID： PMC2238068          DOI： 10.1128/JCM.01729-07

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  16 in total

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