OBJECTIVE: To establish gestation-specific reference intervals for thyroid function tests in normal singleton pregnancy. STUDY DESIGN: Cross-sectional observational study performed in the Obstetric and Gynaecology department, West Middlesex University Hospital. A single blood sample from 335 pregnant women at various gestations of pregnancy was analysed for thyroid function. FT4, fT3, TSH values at each gestation of pregnancy were calculated. RESULTS: From the fT3, fT4 and TSH results, a 95% reference interval was calculated for each hormone for each week of pregnancy. CONCLUSION: We calculated gestation-specific reference intervals for thyroid function tests throughout pregnancy to facilitate clinical management of thyroid disease in pregnancy.
OBJECTIVE: To establish gestation-specific reference intervals for thyroid function tests in normal singleton pregnancy. STUDY DESIGN: Cross-sectional observational study performed in the Obstetric and Gynaecology department, West Middlesex University Hospital. A single blood sample from 335 pregnant women at various gestations of pregnancy was analysed for thyroid function. FT4, fT3, TSH values at each gestation of pregnancy were calculated. RESULTS: From the fT3, fT4 and TSH results, a 95% reference interval was calculated for each hormone for each week of pregnancy. CONCLUSION: We calculated gestation-specific reference intervals for thyroid function tests throughout pregnancy to facilitate clinical management of thyroid disease in pregnancy.