Literature DB >> 18092144

The role of CD4+CD25+ T regulatory cells in autoimmune diseases.

E Toubi1.   

Abstract

Among the several mechanisms that play role in maintaining peripheral self-tolerance is the existence of a unique CD4+CD25+ population of naturally occurring regulatory T (Treg) cells that actively prevent both the activation and the effector function of autoreactive T cells that have escaped different mechanisms of tolerance. Many studies have shown the benefit of targeting this cell population by restoring self-tolerance. Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve that course of autoimmune diseases.

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Year:  2008        PMID： 18092144     DOI： 10.1007/s12016-007-8043-0

Source DB:  PubMed          Journal:  Clin Rev Allergy Immunol        ISSN： 1080-0549            Impact factor:   8.667


  38 in total

Review 1.  About CD4pos CD25pos regulatory cells.

Authors:  C Asseman; M von Herrath
Journal:  Autoimmun Rev       Date:  2002-08       Impact factor: 9.754

2.  Intravenous immunoglobulin therapy affects T regulatory cells by increasing their suppressive function.

Authors:  Aharon Kessel; Hana Ammuri; Regina Peri; Elsa R Pavlotzky; Miri Blank; Yehuda Shoenfeld; Elias Toubi
Journal:  J Immunol       Date:  2007-10-15       Impact factor: 5.422

3.  Toll-like receptor 2 controls expansion and function of regulatory T cells.

Authors:  Roger P M Sutmuller; Martijn H M G M den Brok; Matthijs Kramer; Erik J Bennink; Liza W J Toonen; Bart-Jan Kullberg; Leo A Joosten; Shizuo Akira; Mihai G Netea; Gosse J Adema
Journal:  J Clin Invest       Date:  2006-01-19       Impact factor: 14.808

4.  Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus.

Authors:  Jyh-Hong Lee; Li-Chieh Wang; Yu-Tsan Lin; Yao-Hsu Yang; Dong-Tsamn Lin; Bor-Luen Chiang
Journal:  Immunology       Date:  2006-02       Impact factor: 7.397

5.  Increased spontaneous apoptosis of CD4+CD25+ T cells in patients with active rheumatoid arthritis is reduced by infliximab.

Authors:  E Toubi; A Kessel; Z Mahmudov; K Hallas; M Rozenbaum; I Rosner
Journal:  Ann N Y Acad Sci       Date:  2005-06       Impact factor: 5.691

6.  Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis.

Authors:  Duojia Cao; Vivianne Malmström; Clare Baecher-Allan; David Hafler; Lars Klareskog; Christina Trollmo
Journal:  Eur J Immunol       Date:  2003-01       Impact factor: 5.532

7.  Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus.

Authors:  Elena Yu Lyssuk; Anna V Torgashina; Sergey K Soloviev; Evgeny L Nassonov; Svetlana N Bykovskaia
Journal:  Adv Exp Med Biol       Date:  2007       Impact factor: 2.622

8.  Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA.

Authors:  Antonio La Cava; Fanny M Ebling; Bevra H Hahn
Journal:  J Immunol       Date:  2004-09-01       Impact factor: 5.422

9.  Elimination of CD4+ CD25+ regulatory T cells breaks down reovirus type 2-triggered and CpG ODN-induced prolonged mild autoimmune insulitis in DBA/1 mice.

Authors:  T Hayashi; K Hasegawa; Y Sasaki; T Onodera
Journal:  Scand J Immunol       Date:  2006-02       Impact factor: 3.487

10.  Massive thymic deletion results in systemic autoimmunity through elimination of CD4+ CD25+ T regulatory cells.

Authors:  Fei F Shih; Laura Mandik-Nayak; Brian T Wipke; Paul M Allen
Journal:  J Exp Med       Date:  2004-01-26       Impact factor: 14.307
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  6 in total

1.  Vasculitis: current status and future directions.

Authors:  Pierre Youinou
Journal:  Clin Rev Allergy Immunol       Date:  2008-10       Impact factor: 8.667

2.  Cutting edge issues in autoimmunity.

Authors:  Yaniv Sherer; Torsten Matthias; Yehuda Shoenfeld
Journal:  Clin Rev Allergy Immunol       Date:  2008-06       Impact factor: 8.667

Review 3.  Regulation generation: the suppressive functions of human regulatory T cells.

Authors:  Wendy A Goodman; Kevin D Cooper; Thomas S McCormick
Journal:  Crit Rev Immunol       Date:  2012       Impact factor: 2.214

4.  CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells.

Authors:  Jian Zheng; Yinping Liu; Yu-Lung Lau; Wenwei Tu
Journal:  Cell Mol Immunol       Date:  2010-01       Impact factor: 11.530

Review 5.  Therapeutic strategies for SLE involving cytokines: mechanism-oriented therapies especially IFN-gamma targeting gene therapy.

Authors:  Toshiharu Hayashi
Journal:  J Biomed Biotechnol       Date:  2010-08-17

6.  Attenuation of peripheral regulatory T-cell suppression of skin-homing CD8⁺T cells in atopic dermatitis.

Authors:  Bao-Xiang Zhang; Jun-Cheng Lyu; Hai-Bo Liu; Dian-Qin Feng; Dian-Cai Zhang; Xing-Jie Bi; Zhi-Wu Duan; Gang Ding
Journal:  Yonsei Med J       Date:  2015-01       Impact factor: 2.759
  6 in total

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