Meena Kalluri1, Marc A Judson. 1. Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. kalluri@musc.edu
Abstract
BACKGROUND AND AIM: CA 125 is a glycoprotein expressed by a variety of tissues of mesothelial origin. It has classically been associated with ovarian carcinoma. It has also been reported to be elevated in certain granulomatous conditions. We describe a patient with sarcoidosis and an elevated serum CA 125 level and review the medical literature on this topic. METHODS: We describe a patient with active sarcoidosis and an elevated serum CA 125 level at our institution. A search of medical databases revealed 4 additional cases of sarcoidosis associated with elevated serum CA 125 levels. RESULTS: All 5 patients (our patient and the 4 found in medical databases) were female. Four of the 5 presented with abdominal symptoms or weight loss. Four of the 5 patients had evidence of peritoneal sarcoidosis. Three patients required treatment and their serum CA 125 levels declined. CONCLUSIONS: Peritoneal sarcoidosis may "mimic" ovarian carcinoma in that it may present with peritoneal or abdominal findings and an elevated serum CA 125 level.
BACKGROUND AND AIM: CA 125 is a glycoprotein expressed by a variety of tissues of mesothelial origin. It has classically been associated with ovarian carcinoma. It has also been reported to be elevated in certain granulomatous conditions. We describe a patient with sarcoidosis and an elevated serum CA 125 level and review the medical literature on this topic. METHODS: We describe a patient with active sarcoidosis and an elevated serum CA 125 level at our institution. A search of medical databases revealed 4 additional cases of sarcoidosis associated with elevated serum CA 125 levels. RESULTS: All 5 patients (our patient and the 4 found in medical databases) were female. Four of the 5 presented with abdominal symptoms or weight loss. Four of the 5 patients had evidence of peritoneal sarcoidosis. Three patients required treatment and their serum CA 125 levels declined. CONCLUSIONS:Peritoneal sarcoidosis may "mimic" ovarian carcinoma in that it may present with peritoneal or abdominal findings and an elevated serum CA 125 level.
Authors: In Seon Lee; Sae Byul Kim; Chan Soo Moon; Sung Mo Jung; Song Yee Kim; Eun Young Kim; Ji Ye Jung; Young Ae Kang; Young Sam Kim; Se Kyu Kim; Joon Chang; Moo Suk Park Journal: Tuberc Respir Dis (Seoul) Date: 2012-12-28