OBJECTIVE: It has been established that fluorescence-guided resection using 5-aminolevulinic acid is useful in glioma surgery. In this study, we describe three cases in which even perinecrotic tissue could be recognized as fluorescence positive. METHODS: Three cases of central nervous system disease, showing gadolinium enhancement on magnetic resonance imaging scans, were operated on with the aid of fluorescence derived from 5-aminolevulinic acid. Two of these were diagnosed as radiation necrosis and the other as a neurodegenerative demyelinating disease. RESULTS: In all cases, at least some parts of the gadolinium-enhanced area could be labeled as fluorescence positive, whereas centers of necrotic tissue were negative for fluorescence. Histologically, cell infiltration was marked in each case that showed fluorescence activity. CONCLUSION: Both malignant tumors and the perinecrotic area in radiation necrosis or neurodegenerative disease can be labeled as fluorescence positive using 5-aminolevulinic acid.
OBJECTIVE: It has been established that fluorescence-guided resection using 5-aminolevulinic acid is useful in glioma surgery. In this study, we describe three cases in which even perinecrotic tissue could be recognized as fluorescence positive. METHODS: Three cases of central nervous system disease, showing gadolinium enhancement on magnetic resonance imaging scans, were operated on with the aid of fluorescence derived from 5-aminolevulinic acid. Two of these were diagnosed as radiation necrosis and the other as a neurodegenerative demyelinating disease. RESULTS: In all cases, at least some parts of the gadolinium-enhanced area could be labeled as fluorescence positive, whereas centers of necrotic tissue were negative for fluorescence. Histologically, cell infiltration was marked in each case that showed fluorescence activity. CONCLUSION: Both malignant tumors and the perinecrotic area in radiation necrosis or neurodegenerative disease can be labeled as fluorescence positive using 5-aminolevulinic acid.
Authors: Kimberley S Samkoe; Summer L Gibbs-Strauss; Harold H Yang; S Khan Hekmatyar; P Jack Hoopes; Julia A O'Hara; Risto A Kauppinen; Brian W Pogue Journal: J Biomed Opt Date: 2011-09 Impact factor: 3.170
Authors: Brian W Pogue; Summer Gibbs-Strauss; Pablo A Valdés; Kimberley Samkoe; David W Roberts; Keith D Paulsen Journal: IEEE J Sel Top Quantum Electron Date: 2010-05 Impact factor: 4.544
Authors: David W Roberts; Pablo A Valdés; Brent T Harris; Kathryn M Fontaine; Alexander Hartov; Xiaoyao Fan; Songbai Ji; S Scott Lollis; Brian W Pogue; Frederic Leblond; Tor D Tosteson; Brian C Wilson; Keith D Paulsen Journal: J Neurosurg Date: 2010-04-09 Impact factor: 5.115
Authors: David W Roberts; Jaime J Bravo; Jonathan D Olson; William F Hickey; Brent T Harris; Lananh N Nguyen; Jennifer Hong; Linton T Evans; Xiaoyao Fan; Dennis Wirth; Brian C Wilson; Keith D Paulsen Journal: Oper Neurosurg (Hagerstown) Date: 2019-04-01 Impact factor: 2.703