Literature DB >> 18090053

HIV-1 X4/R5 co-receptor in viral reservoir during suppressive HAART.

Cathia Soulié1, Anne-Geneviève Marcelin, Jade Ghosn, Bahia Amellal, Lambert Assoumou, Sidonie Lambert, Claudine Duvivier, Dominique Costagliola, Christine Katlama, Vincent Calvez.   

Abstract

As immune recovery during HAART is mainly caused by the expansion of X4-naive cells, we studied the evolution of HIV tropism in the reservoir of 34 patients receiving 48 weeks of HAART. No change in virus tropism was observed over time, but patients with X4 viruses had higher HIV-1 proviral DNA levels than patients with R5 viruses. This suggests that CCR5 antagonist activity should not be compromised in patients harbouring R5 viruses before starting HAART.

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Year:  2007        PMID： 18090053     DOI： 10.1097/QAD.0b013e3282f0e3d0

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  8 in total

1.  CD133+ hematopoietic progenitor cells harbor HIV genomes in a subset of optimally treated people with long-term viral suppression.

Authors:  Lucy A McNamara; Adewunmi Onafuwa-Nuga; Nadia T Sebastian; James Riddell; Dale Bixby; Kathleen L Collins
Journal:  J Infect Dis       Date:  2013-04-03       Impact factor: 5.226

Review 2.  Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications.

Authors:  Véronique Avettand-Fènoël; Laurent Hocqueloux; Jade Ghosn; Antoine Cheret; Pierre Frange; Adeline Melard; Jean-Paul Viard; Christine Rouzioux
Journal:  Clin Microbiol Rev       Date:  2016-10       Impact factor: 26.132

3.  Depletion of Gut-Resident CCR5+ Cells for HIV Cure Strategies.

Authors:  David Merriam; Connie Chen; Gema Méndez-Lagares; Kenneth A Rogers; Anthony J Michaels; Jiangli Yan; Paul Casaz; Keith A Reimann; François Villinger; Dennis J Hartigan-O'Connor
Journal:  AIDS Res Hum Retroviruses       Date:  2017-11       Impact factor: 2.205

Review 4.  Clinical significance of HIV-1 coreceptor usage.

Authors:  Hanneke Schuitemaker; Angélique B van 't Wout; Paolo Lusso
Journal:  J Transl Med       Date:  2011-01-27       Impact factor: 5.531

5.  X4 tropic multi-drug resistant quasi-species detected at the time of primary HIV-1 infection remain exclusive or at least dominant far from PHI.

Authors:  Jade Ghosn; Julie Galimand; Stéphanie Raymond; Laurence Meyer; Christiane Deveau; Cécile Goujard; Jacques Izopet; Christine Rouzioux; Marie-Laure Chaix
Journal:  PLoS One       Date:  2011-08-24       Impact factor: 3.240

6.  Limited evolution of inferred HIV-1 tropism while viremia is undetectable during standard HAART therapy.

Authors:  Guinevere Q Lee; Winnie Dong; Theresa Mo; David J H F Knapp; Chanson J Brumme; Conan K Woods; Steve Kanters; Benita Yip; P Richard Harrigan
Journal:  PLoS One       Date:  2014-06-06       Impact factor: 3.240

7.  Frequency and predictors of HIV-1 co-receptor switch in treatment naive patients.

Authors:  Virginie Mortier; Kenny Dauwe; Leen Vancoillie; Delfien Staelens; Filip Van Wanzeele; Dirk Vogelaers; Linos Vandekerckhove; Kristen Chalmet; Chris Verhofstede
Journal:  PLoS One       Date:  2013-11-07       Impact factor: 3.240

8.  Impact of HIV-1 tropism on the emergence of non-AIDS events in HIV-infected patients receiving fully suppressive antiretroviral therapy.

Authors:  Gaetano Maffongelli; Claudia Alteri; Elisa Gentilotti; Ada Bertoli; Alessandra Ricciardi; Vincenzo Malagnino; Valentina Svicher; Maria M Santoro; Luca Dori; Carlo F Perno; Massimo Andreoni; Loredana Sarmati
Journal:  AIDS       Date:  2016-03-13       Impact factor: 4.177
  8 in total

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