| Literature DB >> 18088549 |
Malgorzata Muc-Wierzgon1, Ewa Nowakowska-Zajdel, Teresa Kokot, Andrzej Kozowicz, Andrzej Wiczkowski, Elzbieta Grochowska-Niedworok, Urszula Mazurek, Janusz Wierzgon.
Abstract
The expression of the genes coding TNFalpha and TNF RII receptors (TNF RII: TNFR2 membrane and soluble domain, TNFR2/R7 soluble domain) was analysed in colon cancer at the II and III stage of disease, by estimation of mRNA expression. The study included 80 patients with histopathologically confirmed adenocarcinoma. The number of TNFalpha mRNA, TNFR2 mRNA and TNFR2/R7 mRNA copies were estimated in tumour and healthy tissue. The highest number of mRNA TNF-alpha copies were investigated in all samples of tissue and independently of the stage of disease. Simultaneously, we noticed the largest number of mRNA copies for TNFalpha and TNF R2/R7 in healthy cells at stage III of the disease. It is possible to draw a hypothetical line separating the anti-cancer activity of TNFalpha and its influence on cancer progression.Entities:
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Year: 2006 PMID： 18088549
Source DB: PubMed Journal: J Biol Regul Homeost Agents ISSN： 0393-974X Impact factor: 1.711