Literature DB >> 18087805

Two new triterpene glycosides from the Vietnamese sea cucumber Holothuria scabra.

Nguyen Hai Dang1, Nguyen Van Thanh, Phan Van Kiem, Le Mai Huong, Chau Van Minh, Young Ho Kim.   

Abstract

Two new triterpene glycosides, namely holothurin A3 (1) and A4 (2) were isolated from the methanol extract of the sea cucumber, Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 2D NMR, ESI-MS and HRESI-MS). Compounds 1 and 2 were found to be strongly cytotoxic to both cancer cell lines, KB and Hep-G2, with 50% inhibitory concentrations (IC50) of 0.87 and 0.32 microg/mL (for compound 1) and of 1.12 and 0.57 microg/mL (for compound 2), respectively.

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Year:  2007        PMID： 18087805     DOI： 10.1007/bf02977361

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  16 in total

1.  Cytotoxic effects of three Persian Gulf species of Holothurians.

Authors:  S Mashjoor; M Yousefzadi
Journal:  Iran J Vet Res       Date:  2019       Impact factor: 1.376

2.  Structure elucidation of five novel isomeric saponins from the viscera of the sea cucumber Holothuria lessoni.

Authors:  Yadollah Bahrami; Wei Zhang; Tim Chataway; Chris Franco
Journal:  Mar Drugs       Date:  2014-08-08       Impact factor: 5.118

Review 3.  Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers.

Authors:  Joo-In Park; Hae-Rahn Bae; Chang Gun Kim; Valentin A Stonik; Jong-Young Kwak
Journal:  Front Chem       Date:  2014-09-09       Impact factor: 5.221

4.  Cytotoxic and apoptosis-inducing activity of triterpene glycosides from Holothuria scabra and Cucumaria frondosa against HepG2 cells.

Authors:  Juanjuan Wang; Hua Han; Xiangfeng Chen; Yanghua Yi; Hongxiang Sun
Journal:  Mar Drugs       Date:  2014-07-24       Impact factor: 5.118

Review 5.  Sea Cucumber Glycosides: Chemical Structures, Producing Species and Important Biological Properties.

Authors:  Muhammad Abdul Mojid Mondol; Hee Jae Shin; M Aminur Rahman; Mohamad Tofazzal Islam
Journal:  Mar Drugs       Date:  2017-10-17       Impact factor: 5.118

Review 6.  Mechanisms of cancer cell killing by sea cucumber-derived compounds.

Authors:  Teresa Liliana Wargasetia
Journal:  Invest New Drugs       Date:  2017-09-18       Impact factor: 3.850

7.  Discovery of novel saponins from the viscera of the sea cucumber Holothuria lessoni.

Authors:  Yadollah Bahrami; Wei Zhang; Chris Franco
Journal:  Mar Drugs       Date:  2014-05-09       Impact factor: 5.118

Review 8.  Acetylated Triterpene Glycosides and Their Biological Activity from Holothuroidea Reported in the Past Six Decades.

Authors:  Yadollah Bahrami; Christopher M M Franco
Journal:  Mar Drugs       Date:  2016-08-04       Impact factor: 5.118

9.  Evidence for a Saponin Biosynthesis Pathway in the Body Wall of the Commercially Significant Sea Cucumber Holothuria scabra.

Authors:  Shahida Akter Mitu; Utpal Bose; Saowaros Suwansa-Ard; Luke H Turner; Min Zhao; Abigail Elizur; Steven M Ogbourne; Paul Nicholas Shaw; Scott F Cummins
Journal:  Mar Drugs       Date:  2017-11-07       Impact factor: 5.118

Review 10.  Pharmacological Potential of Sea Cucumbers.

Authors:  Yuri Khotimchenko
Journal:  Int J Mol Sci       Date:  2018-05-02       Impact factor: 5.923
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