| Literature DB >> 18087613 |
Yildiz Uludağ1, Xin Li, Heather Coleman, Stacey Efstathiou, Matthew A Cooper.
Abstract
We describe the detection of specific, conserved DNA sequences of herpes simplex virus (HSV) type 1 by means of a novel, high sensitivity acoustic biosensor. Repeated assays on planar and polymeric carboxylic acid- and biotin-presenting surface chemistries enabled statistical comparison of assay specificity and sensitivity and evaluation of assay Z-factor scores. Using a three minute hybridisation with NeutrAvidin capture for signal enhancement, it was possible to detect HSV viral nucleic acids at 5.2 x 10(-11) M concentration.Entities:
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Year: 2007 PMID： 18087613 DOI： 10.1039/b711850c
Source DB: PubMed Journal: Analyst ISSN： 0003-2654 Impact factor: 4.616