OBJECTIVE: We aimed to investigate the existence of associations between well-established and newly recognized biological and phenotypic features of breast cancer involved in tumor progression and prognosis. METHODS: Ninety-eight cases of invasive breast cancer were assessed for the immunohistochemical expression of estrogen and progesterone receptors, Ki-67, HER2, Akt-1, and Notch-2, using the tissue microarray technique. Data regarding tumor histotype, histological grade, tumor size and lymph node status were collected for each patient and included in the analysis. RESULTS: Several significant associations between histological and/or immunophenotypic features came from the analysis of our data. Positive associations were observed between estrogen and progesterone receptors, tumor grade and proliferation index, tumor grade and HER2, Akt-1 and estrogen receptors, and Notch-2 and HER2. Inverse associations were noted between hormone receptors and tumor grade, hormone receptors and HER2, Akt-1 and tumor grade, and Akt-1 and nodal invasion. CONCLUSIONS: Our results, showing the existence of a number of estrogen receptor-positive tumors with Akt-1 expression, better degree of differentiation, and no lymph node involvement, along with the presence of HER2-positive tumors with strong Notch-2 expression, support the role of Notch and Akt in breast cancer progression and suggest that they may also represent new appealing therapeutic targets. Copyright (c) 2007 S. Karger AG, Basel.
OBJECTIVE: We aimed to investigate the existence of associations between well-established and newly recognized biological and phenotypic features of breast cancer involved in tumor progression and prognosis. METHODS: Ninety-eight cases of invasive breast cancer were assessed for the immunohistochemical expression of estrogen and progesterone receptors, Ki-67, HER2, Akt-1, and Notch-2, using the tissue microarray technique. Data regarding tumor histotype, histological grade, tumor size and lymph node status were collected for each patient and included in the analysis. RESULTS: Several significant associations between histological and/or immunophenotypic features came from the analysis of our data. Positive associations were observed between estrogen and progesterone receptors, tumor grade and proliferation index, tumor grade and HER2, Akt-1 and estrogen receptors, and Notch-2 and HER2. Inverse associations were noted between hormone receptors and tumor grade, hormone receptors and HER2, Akt-1 and tumor grade, and Akt-1 and nodal invasion. CONCLUSIONS: Our results, showing the existence of a number of estrogen receptor-positive tumors with Akt-1 expression, better degree of differentiation, and no lymph node involvement, along with the presence of HER2-positive tumors with strong Notch-2 expression, support the role of Notch and Akt in breast cancer progression and suggest that they may also represent new appealing therapeutic targets. Copyright (c) 2007 S. Karger AG, Basel.
Authors: Jaime Lindsay; Xuanmao Jiao; Toshiyuki Sakamaki; Mathew C Casimiro; Lawrence A Shirley; Thai H Tran; Xiaoming Ju; Manran Liu; Zhiping Li; Chenguang Wang; Sanjay Katiyar; Mahadev Rao; Kathleen G Allen; Robert I Glazer; Changhui Ge; Pamela Stanley; Michael P Lisanti; Hallgeir Rui; Richard G Pestell Journal: Clin Transl Sci Date: 2008-09 Impact factor: 4.689
Authors: Erik W J Mollen; Jonathan Ient; Vivianne C G Tjan-Heijnen; Liesbeth J Boersma; Lucio Miele; Marjolein L Smidt; Marc A G G Vooijs Journal: Front Oncol Date: 2018-11-20 Impact factor: 6.244