Literature DB >> 18086849

Antimycobacterial Activity and Mechanism of Action of NAS-91.

Paul Gratraud1, Namita Surolia, Gurdyal S Besra, Avadhesha Surolia, Laurent Kremer.   

Abstract

The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.

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Year:  2007        PMID： 18086849      PMCID： PMC2258518          DOI： 10.1128/AAC.00968-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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