OBJECTIVE: The study summarizes results of karyometric measurements in epithelial cells of the colorectal mucosa to document evidence of a field effect of preneoplastic development among patients with colorectal adenocarcinoma or adenoma. METHODS: Karyometric analyses were done on high-resolution images of histologic sections from 48 patients with colorectal adenocarcinomas and 44 patients with adenomas and on images from matching normal-appearing mucosa directly adjacent to such lesions, at a 1-cm and 10-cm distance from the lesions or from the rectal mucosa of adenoma patients, as well as from 24 healthy normal controls with no family history of colonic disease. RESULTS: The nuclei recorded in the histologically normal-appearing mucosa of patients with either colorectal adenoma or adenocarcinoma exhibited differences in karyometric features in comparison with nuclei recorded in rectal mucosa from patients who were free of a colonic lesion. These differences were expressed to the same extent in tissue adjacent to the lesions and in normal-appearing tissue as distant as the rectum. CONCLUSIONS: The nuclear chromatin pattern may serve as an integrating biomarker for a preneoplastic development. The field effect might provide an end point in chemopreventive intervention trials.
OBJECTIVE: The study summarizes results of karyometric measurements in epithelial cells of the colorectal mucosa to document evidence of a field effect of preneoplastic development among patients with colorectal adenocarcinoma or adenoma. METHODS: Karyometric analyses were done on high-resolution images of histologic sections from 48 patients with colorectal adenocarcinomas and 44 patients with adenomas and on images from matching normal-appearing mucosa directly adjacent to such lesions, at a 1-cm and 10-cm distance from the lesions or from the rectal mucosa of adenomapatients, as well as from 24 healthy normal controls with no family history of colonic disease. RESULTS: The nuclei recorded in the histologically normal-appearing mucosa of patients with either colorectal adenoma or adenocarcinoma exhibited differences in karyometric features in comparison with nuclei recorded in rectal mucosa from patients who were free of a colonic lesion. These differences were expressed to the same extent in tissue adjacent to the lesions and in normal-appearing tissue as distant as the rectum. CONCLUSIONS: The nuclear chromatin pattern may serve as an integrating biomarker for a preneoplastic development. The field effect might provide an end point in chemopreventive intervention trials.
Authors: Evan S Glazer; Peter H Bartels; Anil R Prasad; Michael L Yozwiak; Hubert G Bartels; Janine G Einspahr; David S Alberts; Robert S Krouse Journal: Cancer Prev Res (Phila) Date: 2011-06-02
Authors: Ashish K Tiwari; Susan E Crawford; Andrew Radosevich; Ramesh K Wali; Yolanda Stypula; Dhananjay P Kunte; Nikhil Mutyal; Sarah Ruderman; Andrew Gomes; Mona L Cornwell; Mart De La Cruz; Jeffrey Brasky; Tina P Gibson; Vadim Backman; Hemant K Roy Journal: Cancer Lett Date: 2011-04-14 Impact factor: 8.679
Authors: Shikhar Uttam; Jana G Hashash; Justin LaFace; David Binion; Miguel Regueiro; Douglas J Hartman; Randall E Brand; Yang Liu Journal: Cancer Prev Res (Phila) Date: 2019-06-04
Authors: Peter H Bartels; Francisco A R Garcia; Cornelia L Trimble; James Kauderer; John Curtin; Peter C Lim; Lisa M Hess; Steven Silverberg; Richard J Zaino; Michael Yozwiak; Hubert G Bartels; David S Alberts Journal: Gynecol Oncol Date: 2011-12-09 Impact factor: 5.482
Authors: Peter H Bartels; Rodolfo Montironi; Marina Scarpelli; Hubert G Bartels; David S Alberts Journal: Anal Quant Cytol Histol Date: 2009-06 Impact factor: 0.302