PURPOSE: Leukocyte telomere length has gained attention as a marker of oxidative damage and age-related diseases, including cancer. We hypothesize that leukocyte telomere length might be able to predict future risk of cancer and examined this in a cohort of patients with Barrett's esophagus, who are at increased risk of esophageal adenocarcinoma and thus were enrolled in a long-term cancer surveillance program. PATIENTS AND METHODS: In this prospective study, telomere length was measured by quantitative PCR in baseline blood samples in a cohort of 300 patients with Barrett's esophagus followed for a mean of 5.8 years. Leukocyte telomere length hazard ratios (HR) for risk of esophageal adenocarcinoma were calculated using multivariate Cox models. RESULTS: Shorter telomeres were associated with increased esophageal adenocarcinoma risk (age-adjusted HR between top and bottom quartiles of telomere length, 3.45; 95% confidence interval, 1.35-8.78; P = 0.009). This association was still significant when individually or simultaneously adjusted for age, gender, nonsteroidal anti-inflammatory drug (NSAID) use, cigarette smoking, and waist-to-hip ratio (HR, 4.18; 95% confidence interval, 1.60-10.94; P = 0.004). The relationship between telomere length and cancer risk was particularly strong among NSAID nonusers, ever smokers, and patients with low waist-to-hip ratio. CONCLUSION: Leukocyte telomere length predicts risk of esophageal adenocarcinoma in patients with Barrett's esophagus independently of smoking, obesity, and NSAID use. These results show the ability of leukocyte telomere length to predict the risk of future cancer and suggest that it might also have predictive value in other cancers arising in a setting of chronic inflammation.
PURPOSE: Leukocyte telomere length has gained attention as a marker of oxidative damage and age-related diseases, including cancer. We hypothesize that leukocyte telomere length might be able to predict future risk of cancer and examined this in a cohort of patients with Barrett's esophagus, who are at increased risk of esophageal adenocarcinoma and thus were enrolled in a long-term cancer surveillance program. PATIENTS AND METHODS: In this prospective study, telomere length was measured by quantitative PCR in baseline blood samples in a cohort of 300 patients with Barrett's esophagus followed for a mean of 5.8 years. Leukocyte telomere length hazard ratios (HR) for risk of esophageal adenocarcinoma were calculated using multivariate Cox models. RESULTS: Shorter telomeres were associated with increased esophageal adenocarcinoma risk (age-adjusted HR between top and bottom quartiles of telomere length, 3.45; 95% confidence interval, 1.35-8.78; P = 0.009). This association was still significant when individually or simultaneously adjusted for age, gender, nonsteroidal anti-inflammatory drug (NSAID) use, cigarette smoking, and waist-to-hip ratio (HR, 4.18; 95% confidence interval, 1.60-10.94; P = 0.004). The relationship between telomere length and cancer risk was particularly strong among NSAID nonusers, ever smokers, and patients with low waist-to-hip ratio. CONCLUSION: Leukocyte telomere length predicts risk of esophageal adenocarcinoma in patients with Barrett's esophagus independently of smoking, obesity, and NSAID use. These results show the ability of leukocyte telomere length to predict the risk of future cancer and suggest that it might also have predictive value in other cancers arising in a setting of chronic inflammation.
Authors: Therese Truong; Rayjean J Hung; Christopher I Amos; Xifeng Wu; Heike Bickeböller; Albert Rosenberger; Wiebke Sauter; Thomas Illig; H-Erich Wichmann; Angela Risch; Hendrik Dienemann; Rudolph Kaaks; Ping Yang; Ruoxiang Jiang; John K Wiencke; Margaret Wrensch; Helen Hansen; Karl T Kelsey; Keitaro Matsuo; Kazuo Tajima; Ann G Schwartz; Angie Wenzlaff; Adeline Seow; Chen Ying; Andrea Staratschek-Jox; Peter Nürnberg; Erich Stoelben; Jürgen Wolf; Philip Lazarus; Joshua E Muscat; Carla J Gallagher; Shanbeh Zienolddiny; Aage Haugen; Henricus F M van der Heijden; Lambertus A Kiemeney; Dolores Isla; Jose Ignacio Mayordomo; Thorunn Rafnar; Kari Stefansson; Zuo-Feng Zhang; Shen-Chih Chang; Jin Hee Kim; Yun-Chul Hong; Eric J Duell; Angeline S Andrew; Flavio Lejbkowicz; Gad Rennert; Heiko Müller; Hermann Brenner; Loïc Le Marchand; Simone Benhamou; Christine Bouchardy; M Dawn Teare; Xiaoyan Xue; John McLaughlin; Geoffrey Liu; James D McKay; Paul Brennan; Margaret R Spitz Journal: J Natl Cancer Inst Date: 2010-06-14 Impact factor: 13.506
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