| Literature DB >> 18086544 |
Ingrid de Chazeron1, Sandrine Daval, Sylvie Ughetto, Damien Richard, Alain Nicolay, Didier Lemery, Pierre M Llorca, François Coudoré.
Abstract
The objective of this study was to measure the plasma cotinine levels in pregnant women and their newborns using a gas chromatography-mass spectrometry (GC-MS) method in an epidemiological-delivered population with a wide range of tobacco intakes. Nearly 1000 pregnant women from regional maternity wards (n=1007) were selected for the study. Each patient kept a tobacco diary and underwent a blood test to assess cotinine levels and at the same time that the newborns' cordonal plasma was taken. These values were then cross-checked. Cotinine was estimated using a selected-ion monitoring mode with a 1.5 ng/ml quantification limit. The cotinine levels in mothers and newborns were highly correlated, whatever the mother's smoking status, with a calculated cut-off for cotinine levels in active smokers of 21.5 ng/ml. Finally, the cotinine determined through this GC-MS method offered a sensitive and accurate measure of tobacco exposition of the pregnant women and their babies.Entities:
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Year: 2007 PMID： 18086544 DOI： 10.1016/j.pupt.2007.11.001
Source DB: PubMed Journal: Pulm Pharmacol Ther ISSN： 1094-5539 Impact factor: 3.410