| Literature DB >> 18086523 |
Kristjan S Gudmundsson1, Brian A Johns, Scott H Allen.
Abstract
Synthesis of a series of 5-substituted as well as 5,7-disubstituted 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-phenylpyrazolo[1,5-a]pyridin-7-amines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar to or better than acyclovir are described.Entities:
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Year: 2007 PMID： 18086523 DOI： 10.1016/j.bmcl.2007.11.120
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823