Literature DB >> 18085376

Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention.

Yoichiro Matsuoka1, Tetsuya Hamaguchi, Katsumi Fukamachi, Midori Yoshida, Gen Watanabe, Kazuyoshi Taya, Hiroyuki Tsuda, Airo Tsubura.   

Abstract

A rat strain carrying the human c-Ha-ras proto-oncogene is highly susceptible to chemically induced mammary carcinogenesis. All the transgenic rats develop preneoplastic mammary lesions within 20 days of an injection of N-methyl-N-nitrosourea, and mammary carcinomas appear within 8 weeks of treatment with a variety of chemical carcinogens. In this review, we summarize molecular aspects of mammary carcinogenesis in transgenic rats and the potential application of this model for studies of breast cancer prevention.

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Year:  2007        PMID： 18085376     DOI： 10.1007/s00795-007-0369-4

Source DB:  PubMed          Journal:  Med Mol Morphol        ISSN： 1860-1499            Impact factor:   2.309


  37 in total

1.  Chemical carcinogen-induced tumorigenesis in parous, involuted mouse mammary glands.

Authors:  D Medina; G H Smith
Journal:  J Natl Cancer Inst       Date:  1999-06-02       Impact factor: 13.506

2.  Protective effects of pregnancy and lactation against N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats.

Authors:  J Yang; K Yoshizawa; S Nandi; A Tsubura
Journal:  Carcinogenesis       Date:  1999-04       Impact factor: 4.944

Review 3.  Comparative study of human and rat mammary tumorigenesis.

Authors:  J Russo; B A Gusterson; A E Rogers; I H Russo; S R Wellings; M J van Zwieten
Journal:  Lab Invest       Date:  1990-03       Impact factor: 5.662

4.  High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.

Authors:  Hiroyuki Tsuda; Katsumi Fukamachi; Yutaka Ohshima; Shinobu Ueda; Yoichiro Matsuoka; Tetsuya Hamaguchi; Takamasa Ohnishi; Nobuo Takasuka; Akihiro Naito
Journal:  Cancer Sci       Date:  2005-06       Impact factor: 6.716

5.  High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis.

Authors:  H Tsuda; M Asamoto; T Ochiya; H Toriyama-Baba; A Naito; T Ota; T Sekiya; M Terada
Journal:  Mutat Res       Date:  2001-06-02       Impact factor: 2.433

6.  Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy.

Authors:  R C Guzman; J Yang; L Rajkumar; G Thordarson; X Chen; S Nandi
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

7.  Short-term exposure to pregnancy levels of estrogen prevents mammary carcinogenesis.

Authors:  L Rajkumar; R C Guzman; J Yang; G Thordarson; F Talamantes; S Nandi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

8.  Chemoprevention of N-nitroso-N-methylurea-induced mammary cancers by pretreatment with 17 beta-estradiol and progesterone.

Authors:  C J Grubbs; D R Farnell; D L Hill; K C McDonough
Journal:  J Natl Cancer Inst       Date:  1985-04       Impact factor: 13.506

Review 9.  Experimentally induced mammary tumors in rats.

Authors:  J Russo; I H Russo
Journal:  Breast Cancer Res Treat       Date:  1996       Impact factor: 4.872

10.  Rapid emergence of mammary preneoplastic and malignant lesions in human c-Ha-ras proto-oncogene transgenic rats: possible application for screening of chemopreventive agents.

Authors:  Yoichiro Matsuoka; Katsumi Fukamachi; Tetsuya Hamaguchi; Hiroyasu Toriyama-Baba; Hiroaki Kawaguchi; Masato Kusunoki; Hiroki Yoshida; Hiroyuki Tsuda
Journal:  Toxicol Pathol       Date:  2003 Nov-Dec       Impact factor: 1.902
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  1 in total

Review 1.  How can grafted breast cancer models be optimized?

Authors:  Séverine Mollard; Yoanne Mousseau; Yasser Baaj; Laurence Richard; Jeanne Cook-Moreau; Jacques Monteil; Benoît Funalot; Franck G Sturtz
Journal:  Cancer Biol Ther       Date:  2011-11-15       Impact factor: 4.742
  1 in total

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