| Literature DB >> 18084261 |
M Emmett1.
Abstract
Fibroblast growth factor 23 (FGF-23) is a phosphate-regulating substance largely produced by osteocytes. Its major action, in normal subjects, is the inhibition of Na-coupled reabsorption of inorganic phosphate in the renal proximal tubule. FGF-23 levels increase markedly in dialysis patients. Why do the FGF-23 levels increase in these patients, and do they have any physiologic or pathophysiologic effects?Entities:
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Year: 2008 PMID: 18084261 DOI: 10.1038/sj.ki.5002651
Source DB: PubMed Journal: Kidney Int ISSN: 0085-2538 Impact factor: 10.612