Literature DB >> 18083858

Heterologous expression of the pneumococcal serotype 14 polysaccharide in Lactococcus lactis requires lactococcal epsABC regulatory genes.

Masja N Nierop Groot1, Jeroen Godefrooij, Michiel Kleerebezem.   

Abstract

The pneumococcal serotype 14 polysaccharide was produced in Lactococcus lactis by coexpressing pneumococcal polysaccharide type 14-specific genes (cpsFGHIJKL(14)) with the lactococcal regulatory and priming glucosyltransferase-encoding genes specific for B40 polysaccharide (epsABCD(B40)). The polysaccharide produced by Lactococcus was secreted in the medium, simplifying downstream processing and polysaccharide isolation from culture broth.

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Year:  2007        PMID： 18083858      PMCID： PMC2227717          DOI： 10.1128/AEM.01655-07

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  17 in total

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Authors:  Judy K Morona; Renato Morona; David C Miller; James C Paton
Journal:  J Bacteriol       Date:  2003-05       Impact factor: 3.490

Review 2.  Infections caused by Streptococcus pneumoniae: clinical spectrum, pathogenesis, immunity, and treatment.

Authors:  D M Musher
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3.  Structural studies on the specific type-14 pneumococcal polysaccharide.

Authors:  B Lindberg; J Lönngren; D A Powell
Journal:  Carbohydr Res       Date:  1977-09       Impact factor: 2.104

4.  Streptococcus pneumoniae type 14 polysaccharide-conjugate vaccines: length stabilization of opsonophagocytic conformational polysaccharide epitopes.

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Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

5.  Covalent linkage between the capsular polysaccharide and the cell wall peptidoglycan of Streptococcus pneumoniae revealed by immunochemical methods.

Authors:  U B Sørensen; J Henrichsen; H C Chen; S C Szu
Journal:  Microb Pathog       Date:  1990-05       Impact factor: 3.738

6.  Effects of structural modifications on some physical characteristics of exopolysaccharides from Lactococcus lactis.

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Journal:  Biopolymers       Date:  2001-09       Impact factor: 2.505

7.  The synthesis of Streptococcus pneumoniae polysaccharide-tetanus toxoid conjugates and the effect of chain length on immunogenicity.

Authors:  C A Laferrière; R K Sood; J M de Muys; F Michon; H J Jennings
Journal:  Vaccine       Date:  1997-02       Impact factor: 3.641

Review 8.  Strategies for the control of pneumococcal diseases.

Authors:  K Mulholland
Journal:  Vaccine       Date:  1999-07-30       Impact factor: 3.641

Review 9.  Immunology of bacterial polysaccharide antigens.

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10.  A maturation protein is essential for production of active forms of Lactococcus lactis SK11 serine proteinase located in or secreted from the cell envelope.

Authors:  P Vos; M van Asseldonk; F van Jeveren; R Siezen; G Simons; W M de Vos
Journal:  J Bacteriol       Date:  1989-05       Impact factor: 3.490
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  3 in total

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2.  Characterization of an Ebosin derivative produced by heterologous gene replacement in Streptomyces sp. 139.

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Journal:  Microb Cell Fact       Date:  2014-07-22       Impact factor: 5.328

3.  Development of Streptococcus pneumoniae Vaccines Using Live Vectors.

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