Literature DB >> 18083555

Conformational analyses of thiirane-based gelatinase inhibitors.

Mijoon Lee1, Dusan Hesek, Qicun Shi, Bruce C Noll, Jed F Fisher, Mayland Chang, Shahriar Mobashery.   

Abstract

SB-3CT is a thiirane-containing inhibitor of the gelatinase class of matrix metalloprotease enzymes. In support of the mechanistic study of this inhibition, the conformational analyses of SB-3CT (and of two methyl-substituted derivatives) were undertaken using X-ray crystallography and molecular dynamics simulation.

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Year:  2007        PMID： 18083555      PMCID： PMC3286628          DOI： 10.1016/j.bmcl.2007.11.131

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

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Review 2.  Extracellular matrix remodelling: the role of matrix metalloproteinases.

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3.  Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

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Review 4.  Matrix metalloproteinases: structures, evolution, and diversification.

Authors:  I Massova; L P Kotra; R Fridman; S Mobashery
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Review 5.  Engineering of selective TIMPs.

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6.  Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor.

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Review 7.  Extracellular proteases as targets for treatment of cancer metastases.

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8.  Metabolism of a highly selective gelatinase inhibitor generates active metabolite.

Authors:  Mijoon Lee; Adriel Villegas-Estrada; Giuseppe Celenza; Bill Boggess; Marta Toth; Gloria Kreitinger; Christopher Forbes; Rafael Fridman; Shahriar Mobashery; Mayland Chang
Journal:  Chem Biol Drug Des       Date:  2007-10-10       Impact factor: 2.817

9.  Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity.

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10.  A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.

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  4 in total

1.  Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue.

Authors:  Peng Tao; Jed F Fisher; Qicun Shi; Thom Vreven; Shahriar Mobashery; H Bernhard Schlegel
Journal:  Biochemistry       Date:  2009-10-20       Impact factor: 3.162

2.  The X-ray structure of carboxypeptidase A inhibited by a thiirane mechanism-based inhibitor.

Authors:  Daniel Fernández; Sebastian Testero; Josep Vendrell; Francesc X Avilés; Shahriar Mobashery
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3.  Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.

Authors:  Christopher Forbes; Qicun Shi; Jed F Fisher; Mijoon Lee; Dusan Hesek; Leticia I Llarrull; Marta Toth; Michael Gossing; Rafael Fridman; Shahriar Mobashery
Journal:  Chem Biol Drug Des       Date:  2009-10-06       Impact factor: 2.817

Review 4.  Matrix metalloproteinases, T cell homing and beta-cell mass in type 1 diabetes.

Authors:  Alexei Y Savinov; Alex Y Strongin
Journal:  Vitam Horm       Date:  2009       Impact factor: 3.421
  4 in total

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