| Literature DB >> 18083554 |
Holly L Deak1, John R Newcomb, Joseph J Nunes, Christina Boucher, Alan C Cheng, Erin F DiMauro, Linda F Epstein, Paul Gallant, Brian L Hodous, Xin Huang, Josie H Lee, Vinod F Patel, Stephen Schneider, Susan M Turci, Xiaotian Zhu.
Abstract
N-3-(Phenylcarbamoyl)arylpyrimidine-5-carboxamides are a novel class of selective Lck inhibitors. This series of compounds derives its selectivity from a hydrogen bond with the gatekeeper Thr316 of the enzyme. X-ray co-crystal structural data, structure-activity relationships, and the synthesis of these inhibitors are reported herein.Entities:
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Year: 2007 PMID： 18083554 DOI： 10.1016/j.bmcl.2007.11.123
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823